SIB-1281
SIB-1281 is a β-secretase inhibitor that inhibits β-site cleavage of amyloid precursor protein (APP) and reduces the production of Aβ peptides. SIB-1281 decreases the generation of Aβ40 and Aβ42, and promotes the secretion of α-sAPP. SIB-1281 can be used in studies related to Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 181139-85-5
- 分子式: C26H39N3O5
- 分子量:473.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
SIB-1281 inhibits Aβ40 and Aβ42 production with an IC50 of 800 nM, potentiates α-sAPP secretion with an EC50 of 650 nM, and does not alter APP holoprotein levels in human glioblastoma cells transfected with wild-type or mutant APP695 cDNAs[1].
SIB-1281 (16 h) inhibits over 95% of all measured Aβ peptide variant production and increases α-sAPP secretion by ~10-fold in human glioblastoma cells stably expressing Swedish/Indiana mutant APP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 181139-85-5
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分子量 473.60
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分子式 C26H39N3O5
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C=O)CC(C)=C)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SIB-1281 関連分類
HY-187132 関連分類
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