Sibrotuzumab
Based on 1 publication(s) in Google Scholar
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.05%
- CAS 番号: 216669-97-5
- 分子量:148.66 kDa
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保管条件:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Sibrotuzumab
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生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
FAP
体外実験
FAP is a serine protease highly expressed in cancer-associated fibroblasts (CAFs), which promote the tumor growth, invasion, and immunosuppression in a variety of solid tumors[2].
Sibrotuzumab conjugates with near-infrared photosensitizer IR700, binds specifically to FAP-positive cells FEF3 and CAF-WI38, and induces cell death under near-infrared light irradiation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CAF-FEF3 and CAF-WI38
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Concentration:Sibrotuzumab-IR700 conjugate: 20 μg/mL
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Incubation Time:6 h
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Result:Inhibited cell viability.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:TE8 and FEF3 xenograft mouse models[2]
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Dosage:50 µg/mouse
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Administration:ip, once daily for 2 days
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Result:Inhibited tumor growth.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized FAP Protein, Human can bind Sibrotuzumab. The EC50 for this effect is 2.909 ng/mL.
化学情報
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CAS 番号 216669-97-5
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性状 Liquid
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分子量 148.66 kDa
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Color Colorless to light yellow
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SMILES
[Sibrotuzumab]
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別名
BIBH 1; Anti-Human FAP Recombinant Antibody
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Labelled Comp Radiopharm
Preclinical Evaluation of [225Ac]Ac-Sibrotuzumab Employing a PEG4-Macropa Site-Specific Chelation Strategy for Targeted Ablation of Cancer-Associated Fibroblasts in Desmoplastic Tumors. [Abstract]2026 Feb;69(2):e70020. PMID: 41666938
純度とドキュメンテーション
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データシート (261 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Scott AM, et al. A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res. 2003 May;9(5):1639-47. [Content Brief]
[2]. Kobayashi T, et al., Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody. Mol Cancer Ther. 2024 Jul 2;23(7):1031-1042. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sibrotuzumab 関連分類
HY-P99269 関連分類
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