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製品番号: HY-N11128

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Solidagonic acid

Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma.

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CAS 番号: 19941-91-4
分子式: C₂₂H₃₄O₄
分子量:362.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Solidagonic acid 構造式

CAS 番号: 19941-91-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Kinesin アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	260.6 μM Compound: 1; SA	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 31753800]
WI-38	IC₅₀	265.3 μM Compound: 1; SA	Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 31753800]

体外実験

Solidagonic acid (1.56-50 µg per spot; 3 days) restores growth in HSET-overproducing TY27 fission yeast cells in a dose-dependent manner^[1].
Solidagonic acid (2.8 μM; 2-3 days) rescues HSET-overproducing YA8 fission yeast cells from lethality, and restores bipolar spindle morphology^[1].
Solidagonic acid (250 µM; 24 h) does not induce multipolar spindle formation or inhibit centrosome clustering in MDA-MB-231 human breast adenocarcinoma cells^[1].
Solidagonic acid (48 h) has low cytotoxicity against MDA-MB-231 human breast adenocarcinoma cells (IC₅₀ = 260.6 µM) and WI-38 normal human fibroblasts (IC₅₀ = 265.3 µM), with no significant selectivity for cancer cells^[1].
Solidagonic acid serves as a bioprobe in studies of HSET function^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HSET-overproducing fission yeast (YA8 strain, HSET-overexpressing TY27 derivative)
Concentration:

2.8 μM
Incubation Time:

2-3 days
Result:

Rescued HSET-overproducing yeast cells from lethality at 2.8 μM, increasing relative cell viability from 6% to 8%.
Reduced the percentage of mitotic cells with abnormal monopolar spindles from 76% to 11% at 2.8 μM, increasing bipolar spindle formation.
Reduced monopolar spindle frequency to 49% at 2.8 μM.
Induced mild off-target cytotoxicity at 2.8 μM, reducing wild-type YA8 cell viability to 81%.

化学情報

CAS 番号 19941-91-4
分子量 362.50
分子式 C₂₂H₃₄O₄
SMILES

O=C(/C=C(CC[C@@]1([C@H]([C@H](C[C@]2(C)C(C)=CCC[C@H]21)OC(C)=O)C)C)\C)O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Compositae
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kurisawa N, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020;28(1):115154. [Content Brief]

[2]. Shoichi Kusumoto, et al. The Structure and the Stereochemistry of Solidagonic Acid, Bulletin of the Chemical Society of Japan, Volume 42, Issue 3, March 1969, Pages 812-820.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Solidagonic acid

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