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United States

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製品番号: HY-187200

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SP-393D

SP-393D is an amidoxime-based prodrug inhibitor targeting dengue virus NS2B/NS3. The EC₅₀ values of SP-393D in Huh7 cells infected with DENV-1, DENV-2, DENV-3 and DENV-4 are 1.41, 0.066, 0.66 and 0.071 μM, respectively, while its CC₅₀ against Huh7 cells is >100 μM. SP-393D exhibits pan-serotypic activity against dengue virus serotypes 1, 2, 3 and 4. SP-393D binds to the allosteric pocket of dengue virus NS2B/NS3 protease and generates additional hydrogen bonding interactions. SP-393D can be used in studies related to dengue virus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₈H₂₅BrN₈O₃
分子量:601.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SP-393D 構造式

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

DENV NS2B-NS3

体外実験

SP-393D (compound 14a) (0.2-100 μM; 48 h) potently inhibits DENV2 replication in human hepatoma Huh7 cells, with an EC₅₀ of 0.06 μM; it also exhibits serotype-pan activity against DENV1, DENV3 and DENV4, with corresponding EC₅₀ values of 1.41 μM, 0.66 μM and 0.071 μM, respectively; and shows no cytotoxicity even at concentrations as high as 100 μM^[1].
The protonated active form of SP-393D binds to the allosteric site of the dengue virus (DENV) NS2B/NS3 protease-helicase complex and forms a variety of stable interactions, thereby inhibiting the protease function associated with viral replication^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 601.45
分子式 C₂₈H₂₅BrN₈O₃
SMILES

O=C(NCC1=CC=C(/C(N)=N/O)C=C1)C2=CC(C3=CC(/C(N)=N/O)=CC=C3)=NC(N4CC(C=CC(Br)=C5)=C5C4)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kiousis D, et al. Design and synthesis of substituted pyrimidines with potent antiviral activity against dengue. European journal of medicinal chemistry. 2026 Jul 09;317:119130. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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