SPAA-52
Based on 1 Customer Validation
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.07%
- CAS 番号: 2837000-75-4
- 分子式: C8H8Br2N2O4S
- 分子量:388.03
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 4 nM (LMW-PTP)[1]
体内実験
| Compound | SPAA-52 | |
| dose route | 2 mg/kg IV | 10 mg/kg PO |
| AUC (0−8 h) (nM h) | 15,100 | 37,300 |
| C0 or Cmax (nM) | 13,400 | 9690 |
| C0 or Cmax unbound (nM) | 332 | 233 |
| Vdss (L/kg) | 0.42 | |
| CL (mL/min/kg) | 5.65 | |
| T1/2 (h) | 1.41 | 4.2 |
| F (%) | 34 |
| Compound | SPAA-52 | |
| dose route | 3 mg/kg PO | |
| AUC (0-12 h) (nM h) | 4660 | |
| Cmax (nM) | 877 | |
| Cmax unbound (nM) | 21 | |
| Vdss (L/kg) | 0.42 | |
| Tmax (h) | 2.0 | |
| T1/2 (h) | 2.4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2837000-75-4
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性状 Solid
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分子量 388.03
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分子式 C8H8Br2N2O4S
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Color White to off-white
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SMILES
O=S(O)(NC(NC1=CC(Br)=C(C)C(Br)=C1)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (257.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5771 mL | 12.8856 mL | 25.7712 mL | 64.4280 mL |
| 5 mM | 0.5154 mL | 2.5771 mL | 5.1542 mL | 12.8856 mL | |
| 10 mM | 0.2577 mL | 1.2886 mL | 2.5771 mL | 6.4428 mL | |
| 15 mM | 0.1718 mL | 0.8590 mL | 1.7181 mL | 4.2952 mL | |
| 20 mM | 0.1289 mL | 0.6443 mL | 1.2886 mL | 3.2214 mL | |
| 25 mM | 0.1031 mL | 0.5154 mL | 1.0308 mL | 2.5771 mL | |
| 30 mM | 0.0859 mL | 0.4295 mL | 0.8590 mL | 2.1476 mL | |
| 40 mM | 0.0644 mL | 0.3221 mL | 0.6443 mL | 1.6107 mL | |
| 50 mM | 0.0515 mL | 0.2577 mL | 0.5154 mL | 1.2886 mL | |
| 60 mM | 0.0430 mL | 0.2148 mL | 0.4295 mL | 1.0738 mL | |
| 80 mM | 0.0322 mL | 0.1611 mL | 0.3221 mL | 0.8054 mL | |
| 100 mM | 0.0258 mL | 0.1289 mL | 0.2577 mL | 0.6443 mL |
SPAA-52 関連分類
HY-151591 関連分類
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