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Tarlatamab

(別名: AMG-757)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the KDs of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the KDs of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research.

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  • 純度 : 99.77%
  • CAS 番号: 2307488-83-9
  • 分子量:105.07 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tarlatamab
  • Experimental Validation Results for Tarlatamab
  • Experimental Validation Results for Tarlatamab
  • Tarlatamab Chemical Structure
    Tarlatamab 構造式
CAS 番号: 2307488-83-9
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Assay Types
  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc

  • 1/16

    Flow cytometry analysis of Jurkat cells labelling CD3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Flow cytometry analysis of DLL3 overexpression HEK293 cells labelling DLL3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Red).

  • Tarlatamab Chemical Structure
    1/16
  • Tarlatamab
  • Flow cytometry analysis of Jurkat cells labelling CD3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Flow cytometry analysis of DLL3 overexpression HEK293 cells labelling DLL3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Red).
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc