TCL1
TCL1 is a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit in the 19S regulatory particle (19S RP) of the proteasome with an IC50 value of approximately 26 μM. TCL1 interferes with the recognition and transport of ubiquitinated proteins by Rpn-13, inhibits the degradation of proteins by the proteasome, and thus affects the balance of intracellular protein metabolism. TCL1 is promising for research of hematological malignancies.
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- CAS 番号: 875165-39-2
- 分子式: C19H14BrClN4O2S
- 分子量:477.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 875165-39-2
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分子量 477.76
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分子式 C19H14BrClN4O2S
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SMILES
O=C(CC1SC2=NN=C(CC3=CC=C(C=C3)Br)N2N=C1C4=CC=C(Cl)C=C4)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Loy CA, et al. ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation. J Med Chem. 2025 May 8;68(9):9694-9705. [Content Brief]
[2]. Winton VJ, et al. Deleterious Consequences of UDP-Galactopyranose Mutase Inhibition for Nematodes. ACS Chem Biol. 2017 Sep 15;12(9):2354-2361. [Content Brief]
[3]. Loy CA, et al. Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers. Bioorg Med Chem Lett. 2023 Oct 15;95:129485. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TCL1 関連分類
HY-159808 関連分類
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