TK-684
TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, ＞1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C17H21ClN8OS
- 分子量:420.92
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
TK-684 (1.25-100 μM; 72 h) inhibits cell proliferative in KYSE-150 cells[1].
TK-684 (0-40 μM; 48 h) induces apoptosis[1].
TK-684 (0-20 μM; 2 h) decreases the protein expression of p-AKT, p-ERK in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:KYSE-150 cells
-
Concentration:1.25-100 μM
-
Incubation Time:72 h
-
Result:Inhibited cell proliferative.
-
Cell Line:KYSE-150 cells
-
Concentration:0-40 μM
-
Incubation Time:48 h
-
Result:Induced cell apoptosis.
-
Cell Line:KYSE-150 cells
-
Concentration:0-20 μM
-
Incubation Time:2 h
-
Result:Decreased the protein expression of p-AKT, p-ERK in a dose-dependent manner.
| Species | Dose | Route | T1/2 | Bioavailability |
|---|---|---|---|---|
| Rat | 10 mg/kg | p.o. | 2.41 h | 0.9 % |
化学情報
-
分子量 420.92
-
分子式 C17H21ClN8OS
-
SMILES
ClC1=C(N=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)N
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TK-684 関連分類
HY-173573 関連分類
Powered by Bioz