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製品番号: HY-N7291

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Tryprostatin A

Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939.

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CAS 番号: 171864-80-5
分子式: C₂₂H₂₇N₃O₃
分子量:381.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tryprostatin A 構造式

CAS 番号: 171864-80-5

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生物活性

製品説明

Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	GI₅₀	79.7 μM Compound: 1, tryprostatin A	Cytotoxicity against human BT549 cells Cytotoxicity against human BT549 cells	[PMID: 18321710]
CCRF-CEM	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human CCRF-CEM cells Cytotoxicity against human CCRF-CEM cells	[PMID: 18321710]
COLO 205	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human COLO205 cells Cytotoxicity against human COLO205 cells	[PMID: 18321710]
DU-145	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 18321710]
EKVX	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human EKVX cells Cytotoxicity against human EKVX cells	[PMID: 18321710]
HepG2	IC₅₀	>50 μM Compound: 3	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38334086]
HL-60	GI₅₀	11.3 μM Compound: 1, tryprostatin A	Cytotoxicity against human HL60 (TB) cells Cytotoxicity against human HL60 (TB) cells	[PMID: 18321710]
HOP-92	GI₅₀	21.2 μM Compound: 1, tryprostatin A	Cytotoxicity against human HOP92 cells Cytotoxicity against human HOP92 cells	[PMID: 18321710]
IGROV-1	GI₅₀	90.5 μM Compound: 1, tryprostatin A	Cytotoxicity against human IGROV1 cells Cytotoxicity against human IGROV1 cells	[PMID: 18321710]
K562	GI₅₀	2.73 μM Compound: 1, tryprostatin A	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 18321710]
K562	IC₅₀	41 μM Compound: 13	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 19256529]
LOX IMVI	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human LOX IMVI cells Cytotoxicity against human LOX IMVI cells	[PMID: 18321710]
MCF7	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human MCF7 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay Cytotoxicity against human MCF7 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay	[PMID: 18321710]
OVCAR-3	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human OVCAR-3 cells Cytotoxicity against human OVCAR-3 cells	[PMID: 18321710]
PC-3	GI₅₀	94 μM Compound: 1, tryprostatin A	Cytotoxicity against human PC3 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay Cytotoxicity against human PC3 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay	[PMID: 18321710]
RPMI-8226	GI₅₀	37.1 μM Compound: 1, tryprostatin A	Cytotoxicity against human RPMI8226 cells Cytotoxicity against human RPMI8226 cells	[PMID: 18321710]
SR	GI₅₀	5.68 μM Compound: 1, tryprostatin A	Cytotoxicity against human SR cells Cytotoxicity against human SR cells	[PMID: 18321710]
UO-31	GI₅₀	>100 μM Compound: 1, tryprostatin A	Cytotoxicity against human UO31 cells Cytotoxicity against human UO31 cells	[PMID: 18321710]

化学情報

CAS 番号 171864-80-5
分子量 381.47
分子式 C₂₂H₂₇N₃O₃
SMILES

O=C(N[C@H]1CC2=C(C/C=C(C)\C)NC3=C2C=CC(OC)=C3)[C@@](CCC4)([H])N4C1=O
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
Aspergillus fumigatus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. CHENG-BIN CUI, et al. Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergillus fumigatus. The Journal of Antibiotics. 1995, 48.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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