Verruculogen
Based on 1 Customer Validation
Verruculogen is a tremorgenic mycotoxin and inhibitor of the M phase of the mammalian cell cycle. Verruculogen is produced by Penicillium and Aspergillus species. Verruculogen enhances the binding of ChTX to maxi-k channels with a K1/2 value of 170 nM. Verruculogen inhibits the amplitude of Ca2+-activated K+ currents. Verruculogen induces severe tremors in infected animals.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.08%
- CAS 番号: 12771-72-1
- 分子式: C27H33N3O7
- 分子量:511.57
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-17398
Mitiglinide calciumK(ATP) Channel Antagonist -
HY-N6725
SterigmatocystineDNA Synthesis Inhibitor -
HY-N6786
Ochratoxin BMycotoxin -
HY-116909
O-MethylsterigmatocystinFungal Metabolites -
HY-125699
Ochratoxin CMycotoxin -
HY-126765
Territrem BFungal Meroterpenoid -
HY-17398R
Mitiglinide calcium (Standard)K(ATP) Channel Antagonist -
HY-N6725R
Sterigmatocystine (Standard) -
HY-N6786R
Ochratoxin B (Standard)Standard of Ochratoxin B
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 27865702] |
| HT-29 | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 27865702] |
| Jurkat | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
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[PMID: 27865702] |
| MCF7 | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 27865702] |
体外実験
Verruculogen enhances ChTX binding to maxi-k channels, with a K1/2 value of 170 nM[2].
Verruculogen (1 μM) significantly inhibits the amplitude of Thymol (HY-N6810)-stimulated Ca2+-activated K+ current (IK(Ca)) in pituitary GH3 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 12771-72-1
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性状 Solid
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分子量 511.57
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分子式 C27H33N3O7
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Color White to light brown
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SMILES
C/C(C)=C\[C@@H]1N2C3=C([C@@H]([C@@]4(N(C([C@@]5([H])N(CCC5)C4=O)=O)[C@@]3([H])CC(C)(OO1)C)O)O)C6=CC=C(OC)C=C62
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Structure Classification
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Initial Source
Penicillium verruculosum
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 50 mg/mL (97.74 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. [Content Brief]
[3]. Cui CB, et al. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo). 1996 Jun;49(6):534-40. [Content Brief]
[4]. Huang MH, et al. Stimulatory actions of thymol, a natural product, on Ca(2+)-activated K(+) current in pituitary GH(3) cells. Planta Med. 2005 Dec;71(12):1093-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9548 mL | 9.7738 mL | 19.5477 mL | 48.8692 mL |
| 5 mM | 0.3910 mL | 1.9548 mL | 3.9095 mL | 9.7738 mL | |
| 10 mM | 0.1955 mL | 0.9774 mL | 1.9548 mL | 4.8869 mL | |
| 15 mM | 0.1303 mL | 0.6516 mL | 1.3032 mL | 3.2579 mL | |
| 20 mM | 0.0977 mL | 0.4887 mL | 0.9774 mL | 2.4435 mL | |
| 25 mM | 0.0782 mL | 0.3910 mL | 0.7819 mL | 1.9548 mL | |
| 30 mM | 0.0652 mL | 0.3258 mL | 0.6516 mL | 1.6290 mL | |
| 40 mM | 0.0489 mL | 0.2443 mL | 0.4887 mL | 1.2217 mL | |
| 50 mM | 0.0391 mL | 0.1955 mL | 0.3910 mL | 0.9774 mL | |
| 60 mM | 0.0326 mL | 0.1629 mL | 0.3258 mL | 0.8145 mL | |
| 80 mM | 0.0244 mL | 0.1222 mL | 0.2443 mL | 0.6109 mL |
Verruculogen 関連分類
HY-N6688 関連分類
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