country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-184883

Copy Link Print Information

VU6035406

VU6035406 is a functionally selective mAChR inhibitor, with mAChR IC₅₀ values of 21 nM, 51 nM and 47 nM against human, rat and mouse targets, respectively. VU6035406 does not act as a P-glycoprotein substrate. VU6035406 shows extremely low inhibitory activity against cytochrome P450 1A2, 2C9, 2D6 and 3A4. VU6035406 can be used in the research of neurological and psychiatric disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2746405-41-2
分子式: C₁₅H₁₆ClN₅O₃S
分子量:381.84

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

VU6035406 構造式

CAS 番号: 2746405-41-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- Parmacokinetics
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

mAChR5

21
nM (IC₅₀, human M5 )

mAChR5

51 nM (IC₅₀, rat M5 (rM5)
)

mAChR5

47 nM (IC₅₀, mouse M5 (mM5))

mAChR アイソフォーム固有の製品をすべて表示 :

体外実験

VU6035406 potently inhibits human M₅ muscarinic acetylcholine receptor-mediated calcium mobilization in hM₅ CHO cells with an IC₅₀ of 21 nM and exhibits >500-fold selectivity over human M₁-M₄ subtypes^[1].
VU6035406 inhibits rat M₅ muscarinic acetylcholine receptor-mediated calcium mobilization with an IC₅₀ of 51 nM and exhibits high selectivity over rat M₁-M₄ subtypes^[1].
VU6035406 inhibits mouse M₅ muscarinic acetylcholine receptor-mediated calcium mobilization with an IC₅₀ of 47 nM^[1].
VU6035406 has a favorable CYP inhibition profile, with no significant inhibition of CYP1A2 or CYP2C9 and weak inhibition of CYP2D6 and CYP3A4^[1].
VU6035406 has low to moderate predicted hepatic clearance across multiple species, favorable unbound fractions in plasma and brain, and moderate brain penetration in rats with a K_p,uu of 0.56^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_inf	Bioavailability	T_1/2	MRT	CL	V_ss
Rat^[1]	1.0 mg/kg	i.v.	/	/	524 ng·h/mL	/	1.0 h	1.3 h	31.8 mL/min/kg	2.37 L/kg
Rat^[1]	10 mg/kg	p.o.	1910 ng/mL	2.0 h	13278 ng·h/mL	>100 %	/	/	/	/
Dog^[1]	3.0 mg/kg	p.o.	699 ng/mL	0.58 h	7070 ng·h/mL	58 %	/	/	/	/

化学情報

CAS 番号 2746405-41-2
分子量 381.84
分子式 C₁₅H₁₆ClN₅O₃S
SMILES

O=S(C1=CN=C(C)O1)(N2CCC(CC2)C3=CN4N=CN=C4C=C3Cl)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Li J, et al. Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M Muscarinic Acetylcholine Receptor. Journal of medicinal chemistry. 2024 Aug 22;67(16):14394-14413. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

VU6035406

mAChR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

VU6035406 関連分類

HY-184883 関連分類

Bioz