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製品番号: HY-155533

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YF704

YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC₅₀=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells.

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CAS 番号: 2956716-97-3
分子式: C₁₇H₂₀Cl₂N₄OS₂
分子量:431.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

YF704 構造式

CAS 番号: 2956716-97-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	12.12 μM Compound: 4w; YF704	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method	[PMID: 37390510]
MDA-MB-468	IC₅₀	14.58 μM Compound: 4w; YF704	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method	[PMID: 37390510]
MV4-11	IC₅₀	3.85 μM Compound: 4w; YF704	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method	[PMID: 37390510]
NCI-H358	IC₅₀	12.01 μM Compound: 4w; YF704	Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method	[PMID: 37390510]

化学情報

CAS 番号 2956716-97-3
分子量 431.40
分子式 C₁₇H₂₀Cl₂N₄OS₂
SMILES

N[C@@H]1[C@H](C)OCC12CCN(CC2)C(S3)=NN=C3SC4=C(Cl)C(Cl)=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu WS, et al. Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer. Eur J Med Chem. 2023 Oct 5;258:115585. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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