KCC2 Modulator-3
Based on 1 Customer Validation
KCC2 Modulator-3 (example 54) is a KCC2 modulator. KCC2 Modulator-3 is used for the research of neurological disorders.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 2704531-38-2
- Formula: C35H39N7O3
- Molecular Weight:605.73
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
KCC2 is the only specific Cl- efflux transporter in mature neurons, which determines the inhibitory function of GABA; decreased expression/activity leads to neuronal hyperexcitability, making it a common core target for epilepsy, neuropathic pain and developmental encephalopathy.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2704531-38-2
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Appearance Solid
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Molecular Weight 605.73
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Formula C35H39N7O3
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Color Off-white to light yellow
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SMILES
O=C1C2=C(CN1C(C)C)C(NC3=CC=C(C4=CC=C(OCCC5(CCC#C)N=N5)C=C4)C=C3)=NC(N6CCOC(C7CC7)C6)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (82.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6509 mL | 8.2545 mL | 16.5090 mL | 41.2725 mL |
| 5 mM | 0.3302 mL | 1.6509 mL | 3.3018 mL | 8.2545 mL | |
| 10 mM | 0.1651 mL | 0.8255 mL | 1.6509 mL | 4.1273 mL | |
| 15 mM | 0.1101 mL | 0.5503 mL | 1.1006 mL | 2.7515 mL | |
| 20 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 2.0636 mL | |
| 25 mM | 0.0660 mL | 0.3302 mL | 0.6604 mL | 1.6509 mL | |
| 30 mM | 0.0550 mL | 0.2752 mL | 0.5503 mL | 1.3758 mL | |
| 40 mM | 0.0413 mL | 0.2064 mL | 0.4127 mL | 1.0318 mL | |
| 50 mM | 0.0330 mL | 0.1651 mL | 0.3302 mL | 0.8255 mL | |
| 60 mM | 0.0275 mL | 0.1376 mL | 0.2752 mL | 0.6879 mL | |
| 80 mM | 0.0206 mL | 0.1032 mL | 0.2064 mL | 0.5159 mL |
KCC2 Modulator-3 Related Classifications
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