2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. KCC2 Modulator-3

KCC2 Modulator-3 (Example 54) is a KCC2 modulator with an EC50 of 0.253  μM. KCC2 Modulator-3 can be used for neurological disorders research, such as epilepsy, neuropathic pain and Rett's syndrme.

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KCC2 Modulator-3

KCC2 Modulator-3 Chemical Structure

CAS No. : 2704531-38-2

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KCC2 Modulator-3 Related Antibodies

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Description

KCC2 Modulator-3 (Example 54) is a KCC2 modulator with an EC50 of 0.253  μM. KCC2 Modulator-3 can be used for neurological disorders research, such as epilepsy, neuropathic pain and Rett's syndrme[1].

Molecular Weight

605.73

Formula

C35H39N7O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=C(CN1C(C)C)C(NC3=CC=C(C4=CC=C(OCCC5(CCC#C)N=N5)C=C4)C=C3)=NC(N6CCOC(C7CC7)C6)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (82.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6509 mL 8.2545 mL 16.5090 mL
5 mM 0.3302 mL 1.6509 mL 3.3018 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6509 mL 8.2545 mL 16.5090 mL 41.2725 mL
5 mM 0.3302 mL 1.6509 mL 3.3018 mL 8.2545 mL
10 mM 0.1651 mL 0.8255 mL 1.6509 mL 4.1273 mL
15 mM 0.1101 mL 0.5503 mL 1.1006 mL 2.7515 mL
20 mM 0.0825 mL 0.4127 mL 0.8255 mL 2.0636 mL
25 mM 0.0660 mL 0.3302 mL 0.6604 mL 1.6509 mL
30 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3758 mL
40 mM 0.0413 mL 0.2064 mL 0.4127 mL 1.0318 mL
50 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8255 mL
60 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.6879 mL
80 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5159 mL
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KCC2 Modulator-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KCC2 Modulator-32704531-38-2Potassium ChannelKcsAModulatorKCC2HEK293 cellsEpilepsyNeuropathic painRett's syndrmeInhibitorinhibitorinhibit

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