(S,S)-BRL-37344
Based on 1 Customer Validation
(S,S)-BRL-37344 is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes.
For research use only. We do not sell to patients.
- Purity: 98.61%
- CAS No.: 90730-96-4
- Formula: C19H22ClNO4
- Molecular Weight:363.84
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
(S,S)-BRL-37344 shows EC50 >1000 nM forβ3, β2 and β1[1].
(S,S)-BRL-37344 does not induce concentration-dependent increases in atria1 rate and weakly induces relaxation of guinea pig trachea[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 90730-96-4
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Appearance Solid
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Molecular Weight 363.84
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Formula C19H22ClNO4
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Color White to off-white
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SMILES
O=C(O)COC1=CC=C(C[C@@H](NC[C@H](C2=CC=CC(Cl)=C2)O)C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
0.5 M NaOH : ≥ 100 mg/mL (274.85 mM)
DMSO : 20 mg/mL (54.97 mM; ultrasonic and adjust pH to 3 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 0.5 M NaOH | 1 mM | 2.7485 mL | 13.7423 mL | 27.4846 mL | 68.7115 mL |
| 5 mM | 0.5497 mL | 2.7485 mL | 5.4969 mL | 13.7423 mL | |
| 10 mM | 0.2748 mL | 1.3742 mL | 2.7485 mL | 6.8712 mL | |
| 15 mM | 0.1832 mL | 0.9162 mL | 1.8323 mL | 4.5808 mL | |
| 20 mM | 0.1374 mL | 0.6871 mL | 1.3742 mL | 3.4356 mL | |
| 25 mM | 0.1099 mL | 0.5497 mL | 1.0994 mL | 2.7485 mL | |
| 30 mM | 0.0916 mL | 0.4581 mL | 0.9162 mL | 2.2904 mL | |
| 40 mM | 0.0687 mL | 0.3436 mL | 0.6871 mL | 1.7178 mL | |
| 50 mM | 0.0550 mL | 0.2748 mL | 0.5497 mL | 1.3742 mL | |
| 0.5 M NaOH | 60 mM | 0.0458 mL | 0.2290 mL | 0.4581 mL | 1.1452 mL |
| 80 mM | 0.0344 mL | 0.1718 mL | 0.3436 mL | 0.8589 mL | |
| 100 mM | 0.0275 mL | 0.1374 mL | 0.2748 mL | 0.6871 mL |
(S,S)-BRL-37344 Related Classifications
HY-101325A Related Classifications
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