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Cat. No.: HY-P2692A

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DT-2

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM).}}

For research use only. We do not sell to patients.

CAS No.: 1220985-78-3
Formula: C₁₂₂H₂₂₃N₅₃O₂₃
Molecular Weight:2800.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DT-2 Chemical Structure

CAS No.: 1220985-78-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM)^[1].}}

Chemical Information

CAS No. 1220985-78-3
Molecular Weight 2800.42
Formula C₁₂₂H₂₂₃N₅₃O₂₃
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-NH2
Sequence Shortening

YGRKKRRQRRRPPLRKKKKKH-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nat Commun

Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice. [Abstract]

2024 Jul 18;15(1):6058. PMID: 39025877
J Ethnopharmacol

Yiqi Huoxue formula promotes post-myocardial infarction angiogenesis by modulating mitochondria-associated membranes (MAMs) and calcium homeostasis via the cGMP/PKG signaling pathway. [Abstract]

2026 Jun 4:370:121936. PMID: 42248375

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pinkse MWH, et al. Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem. 2009 Jun 12;284(24):16354-16368. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Publications (2)
Purity & Documentation
References

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DT-2

Publications Citing Use of MedChemExpress (MCE) DT-2