MAP2K6 - mitogen-activated protein kinase kinase 6 Gene

Also Known as MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5608

About MAP2K6

Cytogenetic location: 17q24.3 Genomic coordinates (GRCh38): 17:69,414,697-69,553,865 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues.

Summary

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and Apoptosis. [provided by RefSeq, Jul 2008]

MAP2K6 Products (2)

mRNA Protein Name
NM_001330450.2 NP_001317379.1 dual specificity mitogen-activated protein kinase kinase 6 isoform 2
NM_002758.4 NP_002749.2 dual specificity mitogen-activated protein kinase kinase 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
8663074 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
19141286 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11035004 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11279118 GOA
Biological Process GO Annotation Evidence References Source
involved in MAPK cascade IDA
IDA: Inferred from direct assay
8663074 GOA
involved in p38MAPK cascade IDA
IDA: Inferred from direct assay
11460167 GOA
involved in stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
8663524 GOA
involved in stress-activated protein kinase signaling cascade IDA
IDA: Inferred from direct assay
35857590 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
9768359 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2K6 Protein Structure

Pkinase

Pkinase: Protein kinase domain (57 - 314)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 6

  • MAPK/ERK kinase 6

MAP2K6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP2K6 P52564 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
20067578
Intra
MAP2K6 P52564 LRRK2 Homo sapiens Q5S007
IF
20067578
Intra
MAP2K6 P52564 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
MAP2K6 P52564 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
MAP2K6 P52564 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
MAP2K6 P52564 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
17255949
Intra
MAP2K6 P52564 MAPK14 Homo sapiens Q16539
Pull Down
32707033
Intra
MAP2K6 P52564 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
MAP2K6 P52564 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
MAP2K6 P52564 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP2K6 Proteins

Cat. No. Product Name Accession Purity
HY-P73811 MKK6 Protein, Human (Active, S207D, T211D, sf9, His-GST) P52564-1 (M1-D334, S207D, T211D) ≥ 88%, as determined by reducing SDS-PAGE.
HY-P74745 MKK6 Protein, Human (sf9, His-GST) P52564-1 (M1-D334) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P74746 MKK6 Protein, Human (sf9) P52564-1 (N-G&P, M1-D334) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74748 MKK6 Protein, Human (S207D, T211D, sf9) P52564-1 (N-G&P, M1-D334, S207D, T211D) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P700592 MAP2K6 Protein, Human (sf9, His) P52564-1 (M1-D334) ≥ 90%, as determined by reducing SDS-PAGE.

MAP2K6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81343 MAP2K6 Antibody (YA1088) WB, IP Human, Rat
HY-P81343A MAP2K6 Antibody (YA1088)(PBS only) WB, IP Human, Rat
HY-P83578 MEK3+MEK6 Antibody (YA3323) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83578A MEK3+MEK6 Antibody (YA3323)(PBS only) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P84382 MAP2K6 Antibody (YA4079) WB, ICC/IF, FC, ELISA Human, Mouse
HY-P84382A MAP2K6 Antibody (YA4079)(PBS only) WB, ICC/IF, FC, ELISA Human, Mouse
HY-P85276 MAP2K6 Antibody (YA4968) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Anthrax Disease

  • Anthrax

  • Ragpicker'S Disease

  • Black Baine

  • Malignant Edema

  • Malignant Pustule

  • Siberian Plague

  • Wool Sorter'S Disease

  • Gas Gangrene

  • Cutaneous Anthrax

  • Anthrax Infection

  • Splenic Fever
Retinitis Pigmentosa 38

  • RP38

  • Rod-Cone Dystrophy, Childhood-Onset

  • Retinitis Pigmentosa, Type 38
Cardiomyopathy, Familial Hypertrophic, 25

  • Hypertrophic Cardiomyopathy 25

  • CMH25

  • Cardiomyopathy, Hypertrophic, 25

  • Cardiomyopathy Familial Hypertrophic 25

  • Cardiomyopathy, Familial Hypertrophic 25

  • Cardiomyopathy, Hypertrophic, Type 25
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08044 MAP2K6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17782 Map2k6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24249 Map2k6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP2K6 RGD RGD:620666
Mus musculus MAP2K6 MGD MGI:1346870
Felis catus MAP2K6 VGNC VGNC:97492
Bos taurus MAP2K6 VGNC VGNC:31187
Macaca mulatta MAP2K6 VGNC VGNC:81456
Canis familiaris MAP2K6 VGNC VGNC:42964
Others MAP2K6 NCBI