ND-2110
ND-2110 is a selective IRAK4 inhibitor (Ki: 7.5 nM). ND-2110 binds to the ATP pocket of IRAK4. ND-2110 targets the subset of activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) cell lines with MYD88 L265P mutations,. ND-2110 inhibits LPS-induced TNF production, alleviates collagen-induced arthritis, and blocks gout formation in mouse models.
For research use only. We do not sell to patients.
- CAS No.: 1388894-17-4
- Formula: C21H28N4O3S
- Molecular Weight:416.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
22 nM
Compound: 7
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Inhibition of CDK8 in human A549 cells by mass spectrometric method
Inhibition of CDK8 in human A549 cells by mass spectrometric method
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[PMID: 28302507] |
Chemical Information
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CAS No. 1388894-17-4
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Molecular Weight 416.54
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Formula C21H28N4O3S
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SMILES
O=C(N)C[C@H]1CCC2=C1C3=C(O[C@@H]4CC[C@@H](N5CCOCC5)CC4)N=CN=C3S2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ND-2110 Related Classifications
HY-117622 Related Classifications
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