VU534
Based on 1 Customer Validation
VU534 is a NAPE-PLD activator, with an EC50 of 0.30 μM. VU534 is dual inhibitors of FAAH and sEH (IC50 of 1.2 μM). VU534 increases efferocytosis in a NAPE-PLD dependent manner. VU534 has the potential for cardiometabolic diseases study [1] .
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 923509-20-0
- Formula: C21H22FN3O3S2
- Molecular Weight:447.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
NAPE-PLD activator, with an EC50 of 0.30 μM
VU534 (up to 30 μM, 24 h) shows minimal cytotoxicity in HepG2 and Raw264.7 cell lines [1].
VU534 (3-30 μM, 1 h) increases NAPE-PLD activity in Raw264.7 cells [1].
VU534 (1 h) increases NAPE-PLD activity in HepG2 cells, with the EC50 values of 1.5 μM[1].
VU534 (5 μM, 1 h) increases NAPE-PLD activity 1.5-fold, but not reverses LEI-401(HY-131181)-inhibited NAPE-PLD activity [1].
VU534 (10 μM, 6 h) significantly enhances efferocytosis in bone-marrow-derived macrophages, but not work in Napepld-/- KO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 923509-20-0
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Appearance Solid
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Molecular Weight 447.55
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Formula C21H22FN3O3S2
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Color White to off-white
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SMILES
CC1=CC(C)=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (55.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2344 mL | 11.1719 mL | 22.3439 mL | 55.8597 mL |
| 5 mM | 0.4469 mL | 2.2344 mL | 4.4688 mL | 11.1719 mL | |
| 10 mM | 0.2234 mL | 1.1172 mL | 2.2344 mL | 5.5860 mL | |
| 15 mM | 0.1490 mL | 0.7448 mL | 1.4896 mL | 3.7240 mL | |
| 20 mM | 0.1117 mL | 0.5586 mL | 1.1172 mL | 2.7930 mL | |
| 25 mM | 0.0894 mL | 0.4469 mL | 0.8938 mL | 2.2344 mL | |
| 30 mM | 0.0745 mL | 0.3724 mL | 0.7448 mL | 1.8620 mL | |
| 40 mM | 0.0559 mL | 0.2793 mL | 0.5586 mL | 1.3965 mL | |
| 50 mM | 0.0447 mL | 0.2234 mL | 0.4469 mL | 1.1172 mL |
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