Cat. No.: HY-N2787

8-Prenylnaringenin

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

8-Prenylnaringenin is an orally active prenyl flavonoid. 8-Prenylnaringenin can be isolated from the hop spike Humulus lupulus. 8-Prenylnaringenin activates the PI3K/Akt pathway and the AMPK pathway, upregulates OXPHOS complexes (II, III, and V) and Sirt1, and reduces ROS production and SOD activity. 8-Prenylnaringenin improves muscle atrophy and obesity and inhibits angiogenesis. 8-Prenylnaringenin exhibits anticancer activity against glioblastoma and colon cancer. 8-Prenylnaringenin also has LH/FSH regulatory activity. 8-prenylnaringenin may be used in bone health research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.63%
CAS No.: 53846-50-7
화학식: C₂₀H₂₀O₅
분자량:340.37

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

8-Prenylnaringenin Chemical Structure

CAS No.: 53846-50-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

SIRT1

All PI3K Isoforms :

All Akt Isoforms :

All AMPK Isoforms :

All Sirtuin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Ishikawa	IC₅₀	19.1 μM Compound: 8-PN	Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay	[PMID: 28812892]
NCI-H460	IC₅₀	3.1 μM Compound: 7	Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C	[PMID: 21275386]

In Vitro

8-Prenylnaringenin (48 h) exhibits strong inhibitory effect against human colon cancer HCT-116 cells with an IC₅₀ value of 23.83 μg/mL^[1].
8-Prenylnaringenin (0.1-10 μM; 0.25-4 h) activates the PI3K/Akt pathway in mouse C2C12 myotubes^[2].
8-Prenylnaringenin (10–500 μM; 24 h) shows higher cytotoxicity against human glioblastoma U-118 MG cells (IC₅₀ ≈ 138 μM) than normal BJ fibroblasts (IC₅₀ = 172 μM)^[3].
8-Prenylnaringenin (0.001-20 μM; 48 h) reduces reactive oxygen species (ROS) production, SOD activity in MCF-7 breast cancer cells^[4].
8-Prenylnaringenin inhibits BME cell invasion with IC₅₀ values ranging from 3 to 10 μM^[5].
8-Prenylnaringenin (1-30 μM) inhibits angiogenesis induced by bFGF, VEGF, or a combination of both cytokines in BME cells in a dose-dependent manner^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

MCF-7 (human breast cancer cell line)
Concentration:

0.01 μM, 1 μM
Incubation Time:

48 h
Result:

Upregulated expression of OXPHOS complexes (II, III, V), Sirt1 (sixfold increase at 1 μM).

In Vivo

8-Prenylnaringenin (0.05% wt/wt in diet for male mice, 0.00005-0.0005% wt/wt in diet for female mice; p.o. via mixed diet) promotes recovery from immobilization-induced disuse muscle atrophy in C57/BL6 mice by activating the Akt phosphorylation pathway^[2].
8-Prenylnaringenin (0.0005%-0.005% wt/wt in high-fat diet; p.o. via mixed diet; 8 weeks) prevents high-fat diet-induced obesity in C57BL/6J male mice by promoting adiponectin secretion and activating the AMPK pathway^[6].
8-Prenylnaringenin (126-1260 ppm; p.o. via soy-free diet; 3 months) suppresses serum LH/FSH levels and stimulates uterine weight in ovariectomized Sprague-Dawley rats^[7].
8-Prenylnaringenin (1.77 mg/kg; s.c.; daily; 10 weeks) does not improve biomechanical properties or bone mineral density of lumbar vertebrae and femora in ovariectomized Sprague-Dawley rats^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (male, 230-290 g initial weight, 5-week-old) fed with high-fat diet^[6].
Dosage:

0.0005% wt/wt, 0.005% wt/wt 8-PN in high-fat diet
Administration:

Oral administration via mixed high-fat diet; 8 weeks
Result:

Prevented high-fat diet-induced body weight gain and fat accumulation in WAT.
Reduced liver total lipid and triglyceride levels in the liver.
Inhibitd ALT activity.
Promoted AMPK phosphorylation.
Regulated SREBP-1 and PGC-1α expression via AMPK activation.

Chemical Information

CAS No. 53846-50-7
Appearance Solid
분자량 340.37
화학식 C₂₀H₂₀O₅
Color White to off-white
SMILES

O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavonones
- Phenols
- Polyphenols
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Bioorg Chem

Enzymatic properties and immobilization of a thermostable prenyltransferase from Aspergillus fumigatiaffinis for the production of prenylated naringenin. [Abstract]

2024 Apr:145:107183. PMID: 38340474

용액&용해도

In Vitro:

DMSO : 100 mg/mL (293.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9380 mL

14.6899 mL

29.3798 mL

5 mM

0.5876 mL

2.9380 mL

5.8760 mL

10 mM

0.2938 mL

1.4690 mL

2.9380 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koosha S, et al. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633. [Content Brief]

[2]. Mukai R, et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031. [Content Brief]

[3]. Stompor M, et al. In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity. Molecules. 2017 Jun 30;22(7). [Content Brief]

[4]. Blanquer-Rosselló MM, et al. Effect of xanthohumol and 8-prenylnaringenin on MCF-7 breast cancer cells oxidative stress and mitochondrial complexes expression. J Cell Biochem. 2013 Dec;114(12):2785-94. [Content Brief]

[5]. Pepper MS, et al. 8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo. J Cell Physiol. 2004 Apr;199(1):98-107. [Content Brief]

[6]. Okada F, et al. 8-Prenylnaringenin suppresses obesity in high-fat diet-fed C57BL/6J mice via adiponectin secretion. J Clin Biochem Nutr. 2025 Jul;77(1):64-73. [Content Brief]

[7]. Christoffel J, et al. Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment. J Endocrinol. 2006 Mar;188(3):397-405. [Content Brief]

[8]. Hoffmann DB, et al. Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia. J Nutr Metab. 2016;2016:6893137. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9380 mL	14.6899 mL	29.3798 mL	73.4495 mL
	5 mM	0.5876 mL	2.9380 mL	5.8760 mL	14.6899 mL
	10 mM	0.2938 mL	1.4690 mL	2.9380 mL	7.3449 mL
	15 mM	0.1959 mL	0.9793 mL	1.9587 mL	4.8966 mL
	20 mM	0.1469 mL	0.7345 mL	1.4690 mL	3.6725 mL
	25 mM	0.1175 mL	0.5876 mL	1.1752 mL	2.9380 mL
	30 mM	0.0979 mL	0.4897 mL	0.9793 mL	2.4483 mL
	40 mM	0.0734 mL	0.3672 mL	0.7345 mL	1.8362 mL
	50 mM	0.0588 mL	0.2938 mL	0.5876 mL	1.4690 mL
	60 mM	0.0490 mL	0.2448 mL	0.4897 mL	1.2242 mL
	80 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9181 mL
	100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7345 mL

Keywords

8-Prenylnaringenin

1 Cited Publications

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8-​Prenylnaringenin

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Publications Citing Use of MedChemExpress (MCE) 8-​Prenylnaringenin

All PI3K Isoforms

All Akt Isoforms

All AMPK Isoforms

All Sirtuin Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

8-​Prenylnaringenin Related Classifications

HY-N2787 Related Classifications

8-Prenylnaringenin

Publications Citing Use of MedChemExpress (MCE) 8-Prenylnaringenin

8-Prenylnaringenin Related Classifications