Topoisomerase Control
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SN-38-CM2
0 ImagesCat. No.: HY-157797CAS No.: 2376127-86-3SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells.
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(R)-Camptothecin
0 ImagesCat. No.: HY-16560BCAS No.: 110351-92-3Synonyms: (R)-Campathecin; (R)-(+)-Camptothecin; (R)-CPT(R)-Camptothecin is an enantiomer of Camptothecin (CPT), is inactive as an inhibitor of the DNA religation reaction and consequently do not poison Top1.
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N,N-Dimethyldoxorubicin
0 ImagesCat. No.: HY-154797CAS No.: 70222-95-6N,N-Dimethyldoxorubicin is a Doxorubicin (HY-15142A) analogue. N,N-Dimethyldoxorubicin shows cytotoxicity against a panel of tumor cell lines (IC50s < 0.3 μM).
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(S)-Benzyl 2-cyclopropyl-2-hydroxyacetate
0 ImagesCat. No.: HY-49556CAS No.: 2414393-48-7(S)-Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin (HY-16560). Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM.
