AMPK activator 10
AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect.
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- CAS No.: 1914176-03-6
- 화학식: C24H26ClFN4O6
- 분자량:520.94
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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AMPK |
AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; orally; single dose) leads to increase in the phosphorylation levels of ACC, which is a downstream target molecule of AMPK, in a dose-dependent manner[1].
AMPK activator 10 (0.5 mg/kg by iv or 1.0 mg/kg by po) has a CL of 9.02 mL/min•kg, a Cmax of 65.4 ng/mL and an AUC of 347 ng•h/mL for rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KKAy mice[1]
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Dosage:0.3, 1, 3 mg/kg
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Administration:Orally; bid; for 21 days
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Result:Exhibited a glucose lowering effect.
The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group.
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Animal Model:Rats[1]
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Dosage:0.5 mg/kg by iv or 1.0 mg/kg by po
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Administration:IV or po
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Result:Had a CL of 9.02 mL/min•kg, a Cmax of 65.4 ng/mL and an AUC of 347 ng•h/mL.
Chemical Information
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CAS No. 1914176-03-6
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분자량 520.94
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화학식 C24H26ClFN4O6
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SMILES
COCCOC1=CC(F)=C(C(CC2)=C1)[C@H]2NC3=C(Cl)C=C(NC(O[C@H]4[C@]5([H])[C@]([C@@H](CO5)O)([H])OC4)=N6)C6=N3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMPK activator 10 Related Classifications
HY-148684 Related Classifications
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