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Cat. No.: HY-146743

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Antitumor agent-53

Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors.

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CAS No.: 2757145-67-6
화학식: C₂₄H₁₈FN₃O
분자량:383.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Antitumor agent-53 Chemical Structure

CAS No.: 2757145-67-6

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Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
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References
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Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.87 μM Compound: 6f	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34990980]
GES1	IC₅₀	12.74 μM Compound: 6c	Antiproliferative activity against human GES1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human GES1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34774339]
GES1	IC₅₀	3.1 μM Compound: 6f	Antiproliferative activity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34990980]
HepG2	IC₅₀	>18 μM Compound: 6f	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34990980]
HepG2	IC₅₀	4.87 μM Compound: 6a	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
HGC-27	IC₅₀	0.37 μM Compound: 6f	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34990980]
HGC-27	IC₅₀	2.5 μM Compound: 6c	Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34774339]
HGC-27	IC₅₀	2.5 μM Compound: 6a	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
HL-60	IC₅₀	11.51 μM Compound: 6a	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
HT-29	IC₅₀	0.53 μM Compound: 6a	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
HT-29	IC₅₀	4.01 μM Compound: 6f	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34990980]
MCF7	IC₅₀	9.11 μM Compound: 6f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34990980]
MGC-803	IC₅₀	0.27 μM Compound: 6c	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34774339]
MGC-803	IC₅₀	0.27 μM Compound: 6a	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
RKO	IC₅₀	5 μM Compound: 6a	Antiproliferative activity against human RKO cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
SGC-7901	IC₅₀	1.67 μM Compound: 6c	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34774339]
SGC-7901	IC₅₀	1.67 μM Compound: 6a	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
SK-HEP1	IC₅₀	16.47 μM Compound: 6a	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
SW480	IC₅₀	4.24 μM Compound: 6a	Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]
U-87MG ATCC	IC₅₀	>18 μM Compound: 6a	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35728506]

In Vitro

Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 µM; 72 h) shows anti-proliferation activity with IC₅₀s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells^[1].
Antitumor agent-53 (0.15, 0.3, 0.6 µM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner^[1].
Antitumor agent-53 (100, 200 µM) shows a certain inhibitory activity against Topo I at 200 μM^[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells^[1].
Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner^[1].
Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner^[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells
Concentration:

0, 0.22, 0.67, 2, 6, 18 µM
Incubation Time:

72 h
Result:

Showed anti-proliferation activity with IC₅₀s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells.

Cell Cycle Analysis^[1]

Cell Line:

HGC-27, HT-29 cells
Concentration:

0.1, 0.3, 0.9 μM
Incubation Time:

24 h
Result:

Cells were arrest at the G2/M phase.

Apoptosis Analysis^[1]

Cell Line:

HGC-27, HT-29 cells
Concentration:

0.1, 0.3, 0.9, 2.7 μM
Incubation Time:

24 h
Result:

Induced the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

HGC-27 cells
Concentration:

0.1, 0.3, 0.9 μM
Incubation Time:

24 h
Result:

Suppressed the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells.

Chemical Information

CAS No. 2757145-67-6
분자량 383.42
화학식 C₂₄H₁₈FN₃O
SMILES

O=C1C2=C(N(C3C4=C(C5=CC=CC=C5N4)CCN13)C6=CC=CC(F)=C6)C=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hao X, et al. Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents. Bioorg Med Chem. 2021; 55:116595. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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