Asoxime dichloride
Based on 1 Customer Validation
Asoxime dichloride (HI-6) is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.47%
- CAS No.: 34433-31-3
- 화학식: C14H16Cl2N4O3
- 분자량:359.21
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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AChE |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice[1]
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Dosage:2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg
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Administration:Intramuscular injection into the rear limb
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Result:Improved vaccination efficacy at the level of immunity regulation by the nervous system.
Chemical Information
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CAS No. 34433-31-3
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Appearance Solid
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분자량 359.21
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화학식 C14H16Cl2N4O3
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Color White to off-white
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SMILES
O/N=C/C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-]
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Synonyms
HI-6
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : 100 mg/mL (278.39 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Pohanka M, et al. HI-6 modulates immunization efficacy in a BALB/c mouse model.Environ Toxicol Pharmacol. 2013 Nov;36(3):801-6. [Content Brief]
[2]. Lundy PM, et al. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev. 2006;25(4):231-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7839 mL | 13.9194 mL | 27.8389 mL | 69.5972 mL |
| 5 mM | 0.5568 mL | 2.7839 mL | 5.5678 mL | 13.9194 mL | |
| 10 mM | 0.2784 mL | 1.3919 mL | 2.7839 mL | 6.9597 mL | |
| 15 mM | 0.1856 mL | 0.9280 mL | 1.8559 mL | 4.6398 mL | |
| 20 mM | 0.1392 mL | 0.6960 mL | 1.3919 mL | 3.4799 mL | |
| 25 mM | 0.1114 mL | 0.5568 mL | 1.1136 mL | 2.7839 mL | |
| 30 mM | 0.0928 mL | 0.4640 mL | 0.9280 mL | 2.3199 mL | |
| 40 mM | 0.0696 mL | 0.3480 mL | 0.6960 mL | 1.7399 mL | |
| 50 mM | 0.0557 mL | 0.2784 mL | 0.5568 mL | 1.3919 mL | |
| 60 mM | 0.0464 mL | 0.2320 mL | 0.4640 mL | 1.1600 mL | |
| 80 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL | 0.8700 mL | |
| 100 mM | 0.0278 mL | 0.1392 mL | 0.2784 mL | 0.6960 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Asoxime dichloride Related Classifications
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