Atz-L5
Atz-L5 is a PD-L1 PTAC (PSMA-targeted chimera) degrader (DC50: 18 pM in PC3-PIP cells; 2 pM in LNCaP cells) and LYTAC. Atz-L5 promotes lysosomal degradation of PD-L1 in PSMA-positive prostate cancer cells. Atz-L5 is applicable to the research of prostate cancer.
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- 화학식: C82H119N13O32
- 분자량:1798.89
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
DC50: PD-L1, 18 pM in PC3-PIP cells; 2 pM in LNCaP cells[1]
Atz-L5 (0.01-100 nM; 24 h) potently degrades PD-L1 in PC3-PIP prostate cancer cells with a DC50 of 18 pM and 70% maximum degradation after 24 h of treatment[1].
Atz-L5 (0.01-10 nM; 24 h) potently degrades PD-L1 in LNCaP prostate cancer cells with a DC50 of 2 pM and 81% maximum degradation after 24 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 1798.89
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화학식 C82H119N13O32
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SMILES
O=C(N(CC1=C2C=CC=C1)C(C=CC=C3)=C3C4=C2N=NN4CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N)=O)CCC(NCCCC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@@H](NC(CC5=CC=C(CNC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)C=C5)=O)CC(O)=O)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atz-L5 Related Classifications
HY-181830 Related Classifications
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