country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-120676

Copy Link Print Information

B-Raf IN 18

B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC₅₀ of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1244644-50-5
화학식: C₃₁H₂₈F₃N₇O₃S₂
분자량:667.72

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

B-Raf IN 18 Chemical Structure

CAS No.: 1244644-50-5

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC₅₀ of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research^[1].

IC₅₀ & Target

B-Raf^V600E

3.8 nM (IC₅₀)

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-MEL-28	EC₅₀	11 nM Compound: 24	Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr	[PMID: 21733693]
SK-MEL-28	EC₅₀	8 nM Compound: 24	Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay	[PMID: 21733693]
SK-MEL-28	IC₅₀	23 nM Compound: 1	Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay	[PMID: 24900673]
SK-MEL-28	IC₅₀	48 nM Compound: 1	Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 24900673]

Chemical Information

CAS No. 1244644-50-5
분자량 667.72
화학식 C₃₁H₂₈F₃N₇O₃S₂
SMILES

O=S(C1=C(C=CC=C1F)F)(NC2=CC=CC(C3=C(SC(C(C)C)=N3)C4=NC(NC5=CC=C(N=C5)N6CCOCC6)=NC=C4)=C2F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Stellwagen JC,et al. Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4436-40. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

B-Raf IN 18

All Raf Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

B-Raf IN 18 Related Classifications

HY-120676 Related Classifications