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Cat. No.: HY-103279

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BIM187

BIM187 is a Bombesin Receptor agonist that induces satiety. BIM187 significantly reduces short-term food intake in rats, but does not alter the total 6 h food intake of rats. BIM187 can be used in studies related to feeding behavior and satiety regulation in rats.

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CAS No.: 137734-88-4
화학식: C₅₃H₇₆N₁₄O₁₀
분자량:1069.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BIM187 Chemical Structure

CAS No.: 137734-88-4

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

BIM187 (0.5-32 μg/kg; i.p.; single dose) induces significant satiety in rats by reducing 30-minute food intake at doses of 4 μg/kg and above, with no effect on total 6-hour food intake, and this satiety effect is independent of CCK-mediated pathways and not antagonized by BIM189 at 20 μg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, starting weight 150-170 g, experimental weight 190-210 g, maintained on 6-hour daily food access, fasted 18 hours prior to experiments)^[1]
Dosage:

0.5 μg/kg; 1 μg/kg; 2 μg/kg; 4 μg/kg; 8 μg/kg; 16 μg/kg; 32 μg/kg
Administration:

i.p.; single dose
Result:

Exerted no meaningful 30-min feeding suppression at 0.5, 1, 2 μg/kg.
Markedly cut 30-min food intake at 4, 8, 16, 32 μg/kg with non-dose-dependent activity.
Suppressed 30-min feeding significantly at 4 μg/kg and left total 6-h intake unchanged versus control.
Lowered 30-min food intake at 32 μg/kg, reduced 60-min intake, with intact total 6-h feeding volume.
Retained full 30-min feeding suppression after co-administration with CCK antagonists BIM18216 (1 mg/kg) and Devazepide (HY-106301) (100 μg/kg).
Maintained unaltered 30-min anorectic action against bombesin antagonist BIM189 (20 μg/kg) at 4 μg/kg.

Chemical Information

CAS No. 137734-88-4
분자량 1069.28
화학식 C₅₃H₇₆N₁₄O₁₀
SMILES

C([C@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)N)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)C(C)C)=O)C)=O)C=3C=4C(NC3)=CC=CC4
Sequence

{d-Phe}-Gln-Trp-Ala-Val-Gly-His-Leu-Leu-NH2
Sequence Shortening

{d-Phe}-QWAVGHLL-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Laferrère B, et al. Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. European journal of pharmacology. 1992 Apr 29;215(1):23-8. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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