BMS-986318
BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.
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- CAS No.: 2314378-09-9
- 화학식: C30H23Cl2F3N4O3
- 분자량:615.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2314378-09-9
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분자량 615.43
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화학식 C30H23Cl2F3N4O3
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SMILES
O=C(C1=CC(C(F)(F)F)=C2C=C(N3CCC4(CC3)C=C(C4)C5=C(C6CC6)ON=C5C7=C(Cl)C=NC=C7Cl)C=CC2=N1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-986318 Related Classifications
HY-139562 Related Classifications
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