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Cat. No.: HY-N19744

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(-)-Calanolide B

(-)-Calanolide B is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC₅₀ of 0.5 mM against HIV-1 RT. (-)-Calanolide B inhibits the replication of HIV-1 IIIb/LAV. (-)-Calanolide B is applicable to research related to HIV-1 infection.

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CAS No.: 909-14-8
화학식: C₂₂H₂₆O₅
분자량:370.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Calanolide B Chemical Structure

CAS No.: 909-14-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

^[1]

HIV-1 RT

0.5 mM (IC₅₀)

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	18.7 μM Compound: (-)-1	Anti-HIV activity against HIV-I RFII strain in CEM cell line Anti-HIV activity against HIV-I RFII strain in CEM cell line	[PMID: 8632437]
CEM-SS	EC₅₀	0.2 μM Compound: 2	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	5.9 μM Compound: 2	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	0.2 μM Compound: (-)-Calanolide B	Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 11430019]
H9	EC₅₀	0.22 μM Compound: 13	Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay	[PMID: 8792623]
H9	IC₅₀	9.8 μM Compound: 13	Cytotoxicity against human H9 cells Cytotoxicity against human H9 cells	[PMID: 8792623]
MT2	IC₅₀	5.89 μM Compound: (-)-1	Anti-HIV activity against HIV-I A17 strain in MT2 cell line Anti-HIV activity against HIV-I A17 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.16 μM Compound: (-)-1	Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.21 μM Compound: (-)-1	Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	7.31 μM Compound: (-)-1	Anti-HIV activity against HIV-I IIIB strain in MT2 cell line Anti-HIV activity against HIV-I IIIB strain in MT2 cell line	[PMID: 8632437]

In Vitro

(-)-Calanolide B (Compound 7) at 1 mM potently inhibits HIV-1 RT, with an IC₅₀ of 0.5 mM and an inhibition rate of 76.2% at 1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 909-14-8
분자량 370.44
화학식 C₂₂H₂₆O₅
SMILES

CCCC(C1=C(O2)C3=C(O[C@H]([C@@H]([C@@H]3O)C)C)C4=C1OC(C)(C=C4)C)=CC2=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Huerta-Reyes M, Basualdo Mdel C, Abe F, et al.. HIV-1 inhibitory compounds from Calophyllum brasiliense leaves. Biological & pharmaceutical bulletin. 2004 Sep;27(9):1471-5. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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