856436-16-3
856436-16-3
Chemical Structure
JI6
- CAS No.: 856436-16-3
- Formula:C19H17N3O4S
- Molecular Weight:383.42
IUPAC Name: (Z)-3-((1H-pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one methanesulfonate
InChIKey: ZUDPNBZMAJGYTE-HYMQDMCPSA-N
SMILES: O=C1NC2=CC=C(C3=CN=CC=C3)C=C2/C1=C/C4=CC=CN4.O=S(O)(C)=O
Biological Activity: JI6 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ～40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits JAK3 and c-Kit, with IC50s of ～250 and ～500 nM, respectively. JI6 can be used for the research of acute myeloid leukemia[1].
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JI6 | JI6 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ～40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits JAK3 and c-Kit, with IC50s of ～250 and ～500 nM, respectively. JI6 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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