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United States

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Cat. No.: HY-18016

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CGI 560

CGI 560 is an inhibitor for Bruton's tyrosine kinase (BTK) with an IC₅₀ of 400 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 845269-74-1
화학식: C₂₉H₂₇N₅O
분자량:461.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CGI 560 Chemical Structure

CAS No.: 845269-74-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CGI 560 is an inhibitor for Bruton's tyrosine kinase (BTK) with an IC₅₀ of 400 nM.

IC₅₀ & Target

IC₅₀: 400 nM (Bruton's tyrosine kinase)

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	400 nM Compound: CGI-560	Inhibition of C-terminal V5-His6 tagged human full-length Btk expressed in Sf9 cells by Lanthascreen assay Inhibition of C-terminal V5-His6 tagged human full-length Btk expressed in Sf9 cells by Lanthascreen assay	[PMID: 30881616]

Chemical Information

CAS No. 845269-74-1
분자량 461.56
화학식 C₂₉H₂₇N₅O
SMILES

O=C(C1=CC=C(C(C)(C)C)C=C1)NC2=CC(C3=CN4C(C(NC5=CC=CC=C5)=N3)=NC=C4)=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lv J, et al., Development of Bruton's Tyrosine Kinase Inhibitors for Rheumatoid Arthritis. Curr Med Chem. 2018;25(42):5847-5859. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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