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Cat. No.: HY-119613

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Clociguanil

Name: Clociguanil
Brand: MedChemExpress
SKU: HY-119613
Availability: PreOrder

(Synonyms: BRL 50216)

Clociguanil (BRL 50216), a DHFR inhibitor (IC₅₀: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action.

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CAS No.: 3378-93-6
화학식: C₁₂H₁₅Cl₂N₅O
분자량:316.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Clociguanil Chemical Structure

CAS No.: 3378-93-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Clociguanil (BRL 50216), a DHFR inhibitor (IC₅₀: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action^[1]^[2].

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Chemical Information

CAS No. 3378-93-6
분자량 316.19
화학식 C₁₂H₁₅Cl₂N₅O
SMILES

NC1=NC(N)=NC(C)(N1OCC2=CC=C(C(Cl)=C2)Cl)C
Synonyms

BRL 50216
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nettleton MJ, et al. The cardiovascular effects of two new triazine antimalarials, BRL 50216 (Clociguanil) and BRL 6231. Toxicol Appl Pharmacol. 1974 Feb;27(2):271-82. [Content Brief]

[2]. Winstanley PA, et al. In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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