country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182304

Copy Link Print Information

CLR01 sodium

CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1. CLR01 sodium reduces amyloid plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1338489-62-5
화학식: C₄₂H₃₀Na₂O₈P₂
분자량:770.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLR01 sodium Chemical Structure

CAS No.: 1338489-62-5

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All α-synuclein Isoforms :

In Vitro

CLR01 binds the N-terminal lysine of the KLVFF peptide with a K_d of 10 μM in PBS buffer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CLR01 (40 μg/kg; daily) reduces cortical plaque load and improves memory and mobility in triply transgenic Alzheimer's disease mice when administered at 40 μg/kg daily^[1].
CLR01 significantly reduces misfolded SOD1 in the spinal cord of G93A-SOD1 ALS mice but does not improve motor function in this fast-progressing model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1338489-62-5
분자량 770.61
화학식 C₄₂H₃₀Na₂O₈P₂
SMILES

O=P(O)(O[Na])OC1=C2C([C@]3([H])C[C@@]2([H])C4=CC([C@]5([H])C6=CC=CC=C6[C@@]7([H])C5)=C7C=C43)=C(C8=C1[C@@]9([H])C%10=CC([C@@]%11([H])C%12=CC=CC=C%12[C@]%13([H])C%11)=C%13C=C%10[C@]8([H])C9)OP(O)(O[Na])=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Hadrovic I, et al. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019;7:657. Published 2019 Oct 1. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CLR01 sodium

All α-synuclein Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CLR01 sodium Related Classifications

HY-182304 Related Classifications