D-Isoleucine
Based on 1 Customer Validation
D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].
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- Purity: 99.83%
- CAS No.: 319-78-8
- 화학식: C6H13NO2
- 분자량:131.18
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Non-natural Amino Acid Compound Library
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High-Throughput Bioactive Compound Library
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3D Diverse Fragment Library
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Biological Activity
D-Isoleucine (1 mM, 2 mM; 15 min) significantly enhances LTP in hippocampal slices and promotes D-serine release from neurons via activation of Asc-1, which is dependent on NMDA receptors[1]. D-Isoleucine can be identified in the supernatant of Staphylococcus aureus grown in RPMI medium, and can be further used to track the amino acid metabolic footprint of the bacteria[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 319-78-8
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Appearance Solid
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분자량 131.18
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화학식 C6H13NO2
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Color White to off-white
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SMILES
CC[C@@H](C)[C@@H](N)C(O)=O
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Synonyms
(R)-Isoleucine
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
H2O : 5.56 mg/mL (42.39 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33(8):3533-44. [Content Brief]
[2]. Dörries K, et al. Metabolic footprint analysis uncovers strain specific overflow metabolism and D-isoleucine production of Staphylococcus aureus COL and HG001. PLoS One. 2013 Dec 3;8(12):e81500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.6234 mL | 38.1170 mL | 76.2340 mL | 190.5851 mL |
| 5 mM | 1.5247 mL | 7.6234 mL | 15.2468 mL | 38.1170 mL | |
| 10 mM | 0.7623 mL | 3.8117 mL | 7.6234 mL | 19.0585 mL | |
| 15 mM | 0.5082 mL | 2.5411 mL | 5.0823 mL | 12.7057 mL | |
| 20 mM | 0.3812 mL | 1.9059 mL | 3.8117 mL | 9.5293 mL | |
| 25 mM | 0.3049 mL | 1.5247 mL | 3.0494 mL | 7.6234 mL | |
| 30 mM | 0.2541 mL | 1.2706 mL | 2.5411 mL | 6.3528 mL | |
| 40 mM | 0.1906 mL | 0.9529 mL | 1.9059 mL | 4.7646 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Isoleucine Related Classifications
HY-I1070 Related Classifications
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