DC0-NH2
Based on 1 Customer Validation
DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.
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- CAS No.: 615538-51-7
- 화학식: C31H24ClN5O3
- 분자량:550.01
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보관:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Duocarmycins |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
30 pM
Compound: 22, C0-NH2
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Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
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[PMID: 22148292] |
| NAMALVA | IC50 |
5 pM
Compound: 22, C0-NH2
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Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
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[PMID: 22148292] |
DC0-NH2 (0-3 nM; 72 hours) is highly potent against Ramos, Namalwa, and HL60/s cells with IC50 values in the 1 pM to 10 pM range, and has 100 pM range when tested on COLO 205 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ramos, Namalwa, HL60/s, and COLO 205 Cancer Cells
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Concentration:0-3 nM
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Incubation Time:72 hours
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Result:Inhibited Namalwa and HL60/s cells with IC50s of 7 and 30 pM, respectively.
Chemical Information
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CAS No. 615538-51-7
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Appearance Solid
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분자량 550.01
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화학식 C31H24ClN5O3
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Color Light brown to brown
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SMILES
O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
DMSO : 50 mg/mL (90.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8181 mL | 9.0907 mL | 18.1815 mL | 45.4537 mL |
| 5 mM | 0.3636 mL | 1.8181 mL | 3.6363 mL | 9.0907 mL | |
| 10 mM | 0.1818 mL | 0.9091 mL | 1.8181 mL | 4.5454 mL | |
| 15 mM | 0.1212 mL | 0.6060 mL | 1.2121 mL | 3.0302 mL | |
| 20 mM | 0.0909 mL | 0.4545 mL | 0.9091 mL | 2.2727 mL | |
| 25 mM | 0.0727 mL | 0.3636 mL | 0.7273 mL | 1.8181 mL | |
| 30 mM | 0.0606 mL | 0.3030 mL | 0.6060 mL | 1.5151 mL | |
| 40 mM | 0.0455 mL | 0.2273 mL | 0.4545 mL | 1.1363 mL | |
| 50 mM | 0.0364 mL | 0.1818 mL | 0.3636 mL | 0.9091 mL | |
| 60 mM | 0.0303 mL | 0.1515 mL | 0.3030 mL | 0.7576 mL | |
| 80 mM | 0.0227 mL | 0.1136 mL | 0.2273 mL | 0.5682 mL |
DC0-NH2 Related Classifications
HY-129379 Related Classifications
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