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Cat. No.: HY-187763

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Dircin

Dircin is a daphnane-type diterpene ester natural product found in the branches and flowers of Dirca occidentalis A. Gray. It exhibits potent cytotoxicity against P-388 lymphocytic leukemia cells, with a ED₅₀ of 0.00000025 μg/mL. Dircin can be used in studies of leukemia and plant-derived cytotoxic daphnane-type diterpene esters.

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CAS No.: 88497-93-2
화학식: C₃₉H₅₂O₁₁
분자량:696.83

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dircin Chemical Structure

CAS No.: 88497-93-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Anti-cancer

Dircin (compound II) potently inhibits P-388 lymphocytic leukemia cells in vitro, with an ED₅₀ of 0.00000025 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Dircin (compound II) (125 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a T/C value of 156% for survival time^[1].
Dircin (62.5 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a survival time T/C value of 147%^[1].
Dircin (31.3 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a survival time T/C value of 125%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six CD2F1 male P-388 tumor-bearing mice^[1]
Dosage:

125 μg/kg
Administration:

Intraperitoneal administration over a 10-day period
Result:

Produced a survival T/C value of 156%.

Animal Model:

Six CD2F1 male P-388 tumor-bearing mice^[1]
Dosage:

62.5 μg/kg
Administration:

Intraperitoneal administration over a 10-day period
Result:

Produced a survival T/C value of 147%.

Animal Model:

Six CD2F1 male P-388 tumor-bearing mice^[1]
Dosage:

31.3 μg/kg
Administration:

Intraperitoneal administration over a 10-day period
Result:

Produced a survival T/C value of 125%.

Related Protocols :

Chemical Information

CAS No. 88497-93-2
분자량 696.83
화학식 C₃₉H₅₂O₁₁
SMILES

C[C@H]1[C@@]23[C@]4([C@]5([C@](CO)(O5)[C@@H](O)[C@@]6(O)[C@]2([C@]([C@H](C)[C@@H]6OC(=O)C7=CC=CC=C7)([C@@H](C)CCCCCC[C@@H](OC(C)=O)[C@@]8(O3)O[C@]4([C@](C(C)=C)(C1)O8)[H])[H])[H])[H])[H]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Badawi MM, et al. Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae). Journal of pharmaceutical sciences. 1983 Nov;72(11):1285-7. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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