DMUP
Based on 1 Customer Validation
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.0%
- CAS No.: 2364350-07-0
- 화학식: C24H24Cl2N2O10Pt
- 분자량:766.44
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 μM for A549, A549/DDP, PANC-1, HepG2 cells, respectively[1].
DMUP (5 μM, 24 h) arrests the cell cycle in S phase in A549 cells[1].
DMUP (5 μM, 48 h) induces apoptosis in A549 cells[1].
DMUP (5 μM, 24 h) decreases the expression of CD47 and SIRPα protein[1].
DMUP (5 μM, 4 h) increases the macrophage phagocytosis in A549-GFP cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A549, A549/DDP, PANC-1, HepG2 cells
-
Concentration:0-64 µM
-
Incubation Time:72 h
-
Result:Showed antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.
-
Cell Line:A549 cells
-
Concentration:5 µM
-
Incubation Time:24 h
-
Result:Arrested the cell cycle in the S phase.
-
Cell Line:A549 cells
-
Concentration:5 µM
-
Incubation Time:48 h
-
Result:Induced cell apoptosis.
-
Cell Line:A549, THP-1 cells
-
Concentration:5 µM
-
Incubation Time:24 h
-
Result:Decreased the expression of CD47 and SIRPα protein.
DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice[1]
-
Dosage:5, 10, 20, 40 mg/kg
-
Administration:i.v., every two days, 18 days
-
Result:Showed low toxicity with LD50 of greater than 20 mg/kg.
-
Animal Model:A549 xenograft BALB/c nude mice[1]
-
Dosage:10 mg/kg
-
Administration:i.v., every other day, 17 day
-
Result:Showed antitumor activity.
Chemical Information
-
CAS No. 2364350-07-0
-
Appearance Solid
-
분자량 766.44
-
화학식 C24H24Cl2N2O10Pt
-
Color White to light yellow
-
SMILES
O=C1OC2=C(C(C)=C1)C=CC(OCC([O-][Pt+4]([Cl-])([O-]C(COC3=CC(OC(C=C4C)=O)=C4C=C3)=O)([NH3])([NH3])[Cl-])=O)=C2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
-
Data Sheet (271 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMUP Related Classifications
HY-115983 Related Classifications
Powered by Bioz