DSPE-PEG2000-Cy5.5
Based on 1 publication(s) in Google Scholar
DSPE-PEG2000-Cy5.5 is a phospholipid-fluorophore conjugate consisting of Cy5.5 covalently linked to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), serving as a surface label for liposomes in multimodal CT/optical imaging.DSPE-PEG2000-Cy5.5 can be used for the research of non-small cell lung cancer.
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- 분자량:2000 (average)
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DSPE-PEG2000-Cy5.5
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Biological Activity
제품 설명
In Vitro
DSPE-PEG2000-Cy5.5 (6.5 mM lipid concentration in FBS; 96 h at 37°C) containing liposomes release less than 25% of their Cy5.5 content over 96 hours of incubation at 37°C in fetal bovine serum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 (athymic female, 6 weeks old, average weight 27 g)[1]
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Dosage:1.8 g lipid/kg body weight (containing DSPE-PEG2000-Cy5.5 at a molar ratio of 0.02 relative to total lipids)
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Administration:tail vein; single injection
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Result:Exhibited a vascular half-life of 36.2 hours.
Showed statistically significant higher accumulation in the liver at 5 minutes and 24 hours postinjection compared to CT-only liposomes.
Showed statistically significant higher accumulation in the kidneys at 48, 72, and 96 hours postinjection compared to CT-only liposomes.
Had accumulation in the spleen equivalent to CT-only liposomes.
Chemical Information
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분자량 2000 (average)
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SMILES
CCCCCCCCCCCCCCCCCC(OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP(OCCNC(OCCNC(CCCCC[N+]1=C(/C=C/C=C/C=C2N(C)C3=C(C4=CC=CC=C4C=C3)C/2(C)C)C(C)(C)C5=C1C=CC6=CC=CC=C56)=O)=O)([O-])=O)=O.[45]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
Programmable nanomotor system responsively and chemotactically captures tumor associated antigens for enhanced in situ cancer vaccine. [Abstract]2025 Nov 11:35:102543. PMID: 41322135
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG2000-Cy5.5 Related Classifications
HY-159194 Related Classifications
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