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Cat. No.: HY-145358

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FAP-PI3KI1

FAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted PI3K inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition.

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CAS No.: 2415941-98-7
화학식: C₅₂H₄₈F₄N₁₀O₁₂S₃
분자량:1177.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FAP-PI3KI1 Chemical Structure

CAS No.: 2415941-98-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All PI3K Isoforms :

Chemical Information

CAS No. 2415941-98-7
분자량 1177.19
화학식 C₅₂H₄₈F₄N₁₀O₁₂S₃
SMILES

O=C(N1[C@@H](CC(F)(C1)F)C#N)[C@H](C)NC(C2=CC=NC(CNC(CCC(N[C@H](C(O)=O)CSSCCOC(OCC3=NC=C(C4=CC=NC5=C4C=C(C6=CN=C(OC)C(NS(=O)(C7=C(C=C(C=C7)F)F)=O)=C6)C=C5)C=C3)=O)=O)=O)=C2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Suraj U Hettiarachchi, et al. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 Oct 28;12(567):eaay3724. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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FAP-PI3KI1

All PI3K Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

FAP-PI3KI1 Related Classifications

HY-145358 Related Classifications