TSSC4 - tumor suppressing subtransferable candidate 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10078

About TSSC4

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:2,400,750-2,403,876 (from NCBI)

This gene has 10 transcripts (splice variants) and 129 orthologues. Ubiquitous expression in testis (RPKM 10.6), bone marrow (RPKM 6.3) and 25 other tissues.

Summary

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast Cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TSSC4 Products (5)

mRNA	Protein	Name
NM_001297658.2	NP_001284587.1	protein TSSC4 isoform a
NM_001297659.2	NP_001284588.1	protein TSSC4 isoform a
NM_001297660.2	NP_001284589.1	protein TSSC4 isoform a
NM_001297661.2	NP_001284590.1	protein TSSC4 isoform b
NM_005706.4	NP_005697.2	protein TSSC4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	35188580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	34131137	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	35188580	GOA
involved in spliceosomal tri-snRNP complex assembly	IMP IMP: Inferred from mutant phenotype	34131137	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U5 snRNP	IDA IDA: Inferred from direct assay	35188580	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	34131137	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34131137	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSSC4 Protein Structure

TSSC4

0
100
200
300
329 a.a.

Protein Preferred Names	Protein Names
protein TSSC4	tumor-suppressing STF cDNA 4 protein

TSSC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSSC4	Q9Y5U2	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	TSSC4	Q9Y5U2	RNF31	Homo sapiens	Q96EP0-3	Y2H Prey Pooling	25416956
Intra	TSSC4	Q9Y5U2	RNF31	Homo sapiens	Q96EP0-3	Validated Y2H	25416956
Intra	TSSC4	Q9Y5U2	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	TSSC4	Q9Y5U2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	TSSC4	Q9Y5U2	KPNA3	Homo sapiens	O00505	Y2H	21516116
Intra	TSSC4	Q9Y5U2	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	TSSC4	Q9Y5U2	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	TSSC4	Q9Y5U2	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	TSSC4	Q9Y5U2	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	TSSC4	Q9Y5U2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	TSSC4	Q9Y5U2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	TSSC4	Q9Y5U2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	TSSC4	Q9Y5U2	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Cardiofaciocutaneous Syndrome 2	CFC2 Cardiofaciocutaneous Syndrome, Type 2
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome	Catshl Syndrome Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS15187	TSSC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSSC4	RGD	RGD:1307043
Canis familiaris	TSSC4	VGNC	VGNC:56098
Mus musculus	TSSC4	MGD	MGI:1861712
Macaca mulatta	TSSC4	VGNC	VGNC:101422
Others	TSSC4	NCBI