CALCRL - calcitonin receptor like receptor Gene

Also Known as CRLR; CGRPR; LMPHM8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10203

About CALCRL

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:187,341,964-187,448,252 (from NCBI)

This gene has 9 transcripts (splice variants), 148 orthologues, 42 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 41.7), fat (RPKM 35.2) and 20 other tissues.

Summary

Enables Adrenomedullin binding activity; Adrenomedullin receptor activity; and Calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP Receptor complex and Adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022]

CALCRL Products (4)

mRNA	Protein	Name
NM_001271751.2	NP_001258680.1	calcitonin gene-related peptide type 1 receptor precursor
NM_001369434.1	NP_001356363.1	calcitonin gene-related peptide type 1 receptor precursor
NM_001369435.1	NP_001356364.1	calcitonin gene-related peptide type 1 receptor precursor
NM_005795.6	NP_005786.1	calcitonin gene-related peptide type 1 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adrenomedullin binding	IPI IPI: Inferred from physical interaction	20074556	GOA
enables adrenomedullin receptor activity	IPI IPI: Inferred from physical interaction	9620797	GOA
enables calcitonin gene-related peptide receptor activity	IPI IPI: Inferred from physical interaction	9620797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16293613	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in adrenomedullin receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	20596610	GOA
involved in calcitonin gene-related peptide receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in calcium ion transport	IDA IDA: Inferred from direct assay	10882736	GOA
involved in cellular response to sucrose stimulus	IDA IDA: Inferred from direct assay	10882736	GOA
involved in protein transport	IDA IDA: Inferred from direct assay	9620797	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	10882736	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CGRP receptor complex	IDA IDA: Inferred from direct assay	9620797	GOA
part of adrenomedullin receptor complex	IDA IDA: Inferred from direct assay	9620797	GOA
part of adrenomedullin receptor complex	IPI IPI: Inferred from physical interaction	22102369	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10882736	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10882736	GOA
located in endosome	IDA IDA: Inferred from direct assay	10882736	GOA
located in lysosome	IDA IDA: Inferred from direct assay	10882736	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	9620797	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10882736	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCRL Protein Structure

HRM

7tm_2

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
calcitonin gene-related peptide type 1 receptor	CGRP type 1 receptor

CALCRL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CALCRL	Q16602	RAMP2	Homo sapiens	O60895	GMS	22102369
Intra	CALCRL	Q16602	RAMP2	Homo sapiens	O60895	Electrophoresis	22102369
Intra	CALCRL	Q16602	RAMP1	Homo sapiens	O60894	X-Ray Diffraction	20826335
Intra	CALCRL	Q16602	RAMP1	Homo sapiens	O60894	GMS	20826335
Intra	CALCRL	Q16602	RAMP1	Homo sapiens	O60894	Confocal	16293613
Intra	CALCRL	Q16602	CALCA	Homo sapiens	P06881	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lymphatic Malformation 8	LMPHM8
Hereditary Lymphedema	Milroy Disease
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Immune Hydrops Fetalis	Ihf Immune Hf Immune Fetal Edema Immune Fetal Hydrops
Primary Lymphedema	Lymphedema Primary
Acute Closed-Angle Glaucoma	Acute Angle-Closure Glaucoma
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Leopard Syndrome 2	LPRD2 Noonan Syndrome With Multiple Lentigines 2 Leopard Syndrome, Type 2
Cartilage Cancer	Chondrogenic Neoplasm
Hypotrichosis-Lymphedema-Telangiectasia Syndrome	HLTS Hypotrichosis Lymphedema Telangiectasia Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Lutembacher'S Syndrome	Lutembacher Syndrome Lutembacher'S Anomaly
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS01835	CALCRL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20140	Calcrl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26644	Calcrl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CALCRL	MGD	MGI:1926944
Rattus norvegicus	CALCRL	RGD	RGD:2255
Canis familiaris	CALCRL	VGNC	VGNC:38665
Felis catus	CALCRL	VGNC	VGNC:107492
Bos taurus	CALCRL	VGNC	VGNC:26705
Macaca mulatta	CALCRL	VGNC	VGNC:70573
Others	CALCRL	NCBI