SP140 - SP140 nuclear body protein Gene

Also Known as LYSP100; LYSP100-A; LYSP100-B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11262

About SP140

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,186,151-230,316,571 (from NCBI)

This gene has 14 transcripts (splice variants), 96 orthologues and 20 paralogues. Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues.

Summary

This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

SP140 Products (5)

mRNA Protein Name
NM_001005176.3 NP_001005176.1 nuclear body protein SP140 isoform 2
NM_001278451.2 NP_001265380.1 nuclear body protein SP140 isoform 3
NM_001278452.2 NP_001265381.1 nuclear body protein SP140 isoform 4
NM_001278453.2 NP_001265382.1 nuclear body protein SP140 isoform 5
NM_007237.5 NP_009168.4 nuclear body protein SP140 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24267382 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP140 Protein Structure

HSR

HSR: HSR domain (37 - 138)

SAND

SAND: SAND domain (580 - 660)

PHD

PHD: PHD-finger (693 - 735)

Bromodomain

Bromodomain: Bromodomain (794 - 836)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 867 a.a.
Protein Preferred Names Protein Names

nuclear body protein SP140

  • lymphoid-restricted homolog of Sp100

SP140 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SP140 Q13342 PIN1 Homo sapiens Q13526
NMR
24267382
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatic Venoocclusive Disease With Immunodeficiency

  • VODI

  • Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome

  • Hepatic Veno-Occlusive Disease With Immunodeficiency

  • Familial Veno-Occlusive Disease With Immunodeficiency

  • Veno-Occlusive Disease And Immunodeficiency Syndrome

  • Vodi Syndrome

  • Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-148591 GSK761 Inhibitor 99.64% Unkown
HY-RS13603 SP140 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13604 SP140L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20495 Sp140 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27003 Sp140 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SP140 VGNC VGNC:59096
Macaca mulatta SP140 VGNC VGNC:77936
Rattus norvegicus SP140 RGD RGD:1306355
Mus musculus SP140 MGD MGI:3702467
Others SP140 NCBI