ECH1 - enoyl-CoA hydratase 1 Gene

Also Known as HPXEL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1891

About ECH1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,815,422-38,831,794 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 190 orthologues and 13 paralogues. Ubiquitous expression in liver (RPKM 139.0), fat (RPKM 120.0) and 25 other tissues.

Summary

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]

ECH1 Products (1)

mRNA Protein Name
NM_001398.3 NP_001389.2 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECH1 Protein Structure

ECH_1

ECH_1: Enoyl-CoA hydratase/isomerase (62 - 316)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

  • delta3,5-delta2,4-dienoyl-CoA isomerase

ECH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ECH1 Q13011 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
ECH1 Q13011 ECI2 Homo sapiens O75521
Anti Tag CoIP
33961781
Intra
ECH1 Q13011 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra
ECH1 Q13011 HTT Homo sapiens P42858
Pull Down
15383276
Intra
ECH1 Q13011 STAT3 Homo sapiens P40763
Pull Down
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ECH1 Proteins

Cat. No. 상품명 Accession Purity
HY-P70059 ECH1 Protein, Human (His) Q13011 (T34-L328) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS04136 ECH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04140 ECHS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19129 Ech1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19188 Echs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25619 Ech1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25676 Echs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ECH1 MGD MGI:1858208
Felis catus ECH1 VGNC VGNC:97408
Rattus norvegicus ECH1 RGD RGD:69353
Bos taurus ECH1 VGNC VGNC:28305
Canis familiaris ECH1 VGNC VGNC:40184
Others ECH1 NCBI