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DESI1 - desumoylating isopeptidase 1 Gene

Also Known as POST; DESI2; DeSI-1; PPPDE2; FAM152B; D15Wsu75e; DJ347H13.4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27351

About DESI1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,598,028-41,621,043 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 7.4), esophagus (RPKM 4.9) and 25 other tissues.

Summary

Enables importin-alpha family protein binding activity. Involved in protein export from nucleus and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

DESI1 Products (1)

mRNA	Protein	Name
NM_015704.3	NP_056519.1	desumoylating isopeptidase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables importin-alpha family protein binding	IPI IPI: Inferred from physical interaction	29666234	GOA
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	35427157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29666234	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein export from nucleus	IPI IPI: Inferred from physical interaction	29666234	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29666234	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	29666234	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	29666234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DESI1 Protein Structure

Peptidase_C97

0
100
168 a.a.

Protein Preferred Names	Protein Names
desumoylating isopeptidase 1	PPPDE peptidase domain containing 2

DESI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DESI1	Q6ICB0	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	DESI1	Q6ICB0	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	CTAG2	Homo sapiens	O75638-2	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	CTAG2	Homo sapiens	O75638-2	Y2H Array	32296183
Intra	DESI1	Q6ICB0	UBQLNL	Homo sapiens	Q8IYU4	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	UBQLNL	Homo sapiens	Q8IYU4	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	UBQLNL	Homo sapiens	Q8IYU4	Y2H Array	32296183
Intra	DESI1	Q6ICB0	UHRF2	Homo sapiens	Q96PU4-2	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	PRR5	Homo sapiens	P85299-2	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	PRR5	Homo sapiens	P85299-2	Y2H Array	32296183
Intra	DESI1	Q6ICB0	SHISA5	Homo sapiens	Q8N114-3	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	SHISA5	Homo sapiens	Q8N114-3	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	SHISA5	Homo sapiens	Q8N114-3	Y2H Array	32296183
Intra	DESI1	Q6ICB0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	DESI1	Q6ICB0	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
Intra	DESI1	Q6ICB0	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	DESI1	Q6ICB0	SHISA4	Homo sapiens	Q96DD7	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	SHISA4	Homo sapiens	Q96DD7	Y2H Array	32296183
Intra	DESI1	Q6ICB0	SHISA4	Homo sapiens	Q96DD7	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	KLRF1	Homo sapiens	Q4KN05	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	KLRF1	Homo sapiens	Q4KN05	Y2H Array	32296183
Intra	DESI1	Q6ICB0	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	DESI1	Q6ICB0	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	SMIM21	Homo sapiens	Q3B7S5	Y2H Array	32296183
Intra	DESI1	Q6ICB0	SMIM21	Homo sapiens	Q3B7S5	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	CDIP1	Homo sapiens	Q9H305	Y2H Array	32296183
Intra	DESI1	Q6ICB0	CDIP1	Homo sapiens	Q9H305	MAPPIT	32296183
Intra	DESI1	Q6ICB0	CDIP1	Homo sapiens	Q9H305	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	UBC	Homo sapiens	P0CG48	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	UBC	Homo sapiens	P0CG48	Y2H Array	32296183
Intra	DESI1	Q6ICB0	UBA52	Homo sapiens	P62987	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	UBA52	Homo sapiens	P62987	Y2H Array	32296183
Intra	DESI1	Q6ICB0	RPS27A	Homo sapiens	P62979	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	RPS27A	Homo sapiens	P62979	Y2H Array	32296183
Intra	DESI1	Q6ICB0	NT5C3A	Homo sapiens	Q9H0P0	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	DESI1	Q6ICB0	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	NME3	Homo sapiens	Q13232	Y2H Array	32296183
Intra	DESI1	Q6ICB0	NME3	Homo sapiens	Q13232	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	DESI1	Q6ICB0	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	DESI1	Q6ICB0	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	DESI1	Q6ICB0	ERP29	Homo sapiens	P30040	Y2H Array	32296183
Intra	DESI1	Q6ICB0	ERP29	Homo sapiens	P30040	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	DESI1	Q6ICB0	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	DESI1	Q6ICB0	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pulmonary Aspergilloma
Parkinson Disease 7, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 7 PARK7 Parkinson'S Disease 7 Autosomal Recessive Early-Onset Parkinson'S Disease 7 Parkinson Disease 7 Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2 Autosomal Recessive Early-Onset Parkinson Disease Type 7 Parkinson Disease, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS03704	DESI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03705	DESI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DESI1	VGNC	VGNC:71702
Bos taurus	DESI1	VGNC	VGNC:28014
Mus musculus	DESI1	MGD	MGI:106313
Rattus norvegicus	DESI1	RGD	RGD:1305776
Canis familiaris	DESI1	VGNC	VGNC:39906
Felis catus	DESI1	VGNC	VGNC:83865
Others	DESI1	NCBI