HCRTR1 - hypocretin receptor 1 Gene

Also Known as OX1R; OXR1; ORXR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3061

About HCRTR1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,617,689-31,634,492 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]

HCRTR1 Products (3)

mRNA Protein Name
XM_024446605.2 XP_024302373.1 orexin/Hypocretin receptor type 1 isoform X1
NM_001525.3 NP_001516.2 orexin/Hypocretin receptor type 1
XM_017001107.2 XP_016856596.1 orexin/Hypocretin receptor type 1 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables orexin receptor activity IDA
IDA: Inferred from direct assay
26950369 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31668922 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
26950369 GOA
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
26950369 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26950369 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCRTR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (63 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
Protein Preferred Names Protein Names

orexin/Hypocretin receptor type 1

  • hypocretin (orexin) receptor 1

  • hypocretin receptor type 1

  • orexin receptor 1

  • orexin receptor type 1

HCRTR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HCRTR1 O43613 APLNR Homo sapiens P35414
BRET
31668922
Intra
HCRTR1 O43613 APLNR Homo sapiens P35414
IF
31668922
Intra
HCRTR1 O43613 APLNR Homo sapiens P35414
Anti Tag CoIP
31668922
Cross: Cross-species interaction Intra: Intraspecies interaction

HCRTR1 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P811197 Orexin Receptor 1 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Morphine Dependence
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Eating Disorder

  • Eating Disorders

  • Feeding And Eating Disorders
Von Economo'S Disease

  • Encephalitis Lethargica

  • Von Economo Encephalitis

  • Von Economo Disease
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Adrenal Cortical Adenoma

  • Adrenocortical Adenoma

  • Adenoma Adrenocortical
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Agoraphobia

  • Fear Of Open Spaces

  • Phobia Of Going Out
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS06051 HCRTR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06052 Hcrtr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06053 Hcrtr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HCRTR1 VGNC VGNC:41623
Rattus norvegicus HCRTR1 RGD RGD:2787
Macaca mulatta HCRTR1 VGNC VGNC:73356
Bos taurus HCRTR1 VGNC VGNC:29781
Mus musculus HCRTR1 MGD MGI:2385650
Felis catus HCRTR1 VGNC VGNC:67544
Others HCRTR1 NCBI