PRDM10 - PR/SET domain 10 Gene

Also Known as PFM7; TRIS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56980

About PRDM10

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,899,711-130,002,835 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 36 paralogues. Ubiquitous expression in skin (RPKM 1.6), lymph node (RPKM 1.5) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several Other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PRDM10 Products (14)

mRNA Protein Name
NM_001367890.1 NP_001354819.1 PR domain zinc finger protein 10 isoform 10
NM_001367891.1 NP_001354820.1 PR domain zinc finger protein 10 isoform 7
NM_001367892.1 NP_001354821.1 PR domain zinc finger protein 10 isoform 6
NM_001367893.1 NP_001354822.1 PR domain zinc finger protein 10 isoform 5
NM_001367894.1 NP_001354823.1 PR domain zinc finger protein 10 isoform 11
NM_001367895.1 NP_001354824.1 PR domain zinc finger protein 10 isoform 14
NM_001367896.1 NP_001354825.1 PR domain zinc finger protein 10 isoform 13
NM_001367897.1 NP_001354826.1 PR domain zinc finger protein 10 isoform 12
NM_001367898.1 NP_001354827.1 PR domain zinc finger protein 10 isoform 9
NM_001367899.1 NP_001354828.1 PR domain zinc finger protein 10 isoform 8
NM_020228.3 NP_064613.2 PR domain zinc finger protein 10 isoform 1
NM_199437.2 NP_955469.1 PR domain zinc finger protein 10 isoform 2
NM_199438.2 NP_955470.1 PR domain zinc finger protein 10 isoform 3
NM_199439.2 NP_955471.1 PR domain zinc finger protein 10 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
36440963 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
36440963 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
31143550 GOA
Cellular Component GO Annotation Evidence References Source
is active in chromatin IDA
IDA: Inferred from direct assay
36440963 GOA
located in chromatin IDA
IDA: Inferred from direct assay
31143550 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
36440963 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
31143550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM10 Protein Structure

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (357 - 377)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (530 - 552)

zf-met

zf-met: Zinc-finger of C2H2 type (561 - 580)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (616 - 639)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (644 - 666)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (674 - 695)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (773 - 795)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (835 - 857)

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  • 1160 a.a.
Protein Preferred Names Protein Names

PR domain zinc finger protein 10

  • PR domain 10

PRDM10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRDM10 Q9NQV6 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
PRDM10 Q9NQV6 REL Homo sapiens Q04864
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

PRDM10 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P810835 PRDM10 Antibody (YA10078) WB Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS11060 PRDM10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PRDM10 VGNC VGNC:44945
Felis catus PRDM10 VGNC VGNC:64343
Bos taurus PRDM10 VGNC VGNC:33289
Macaca mulatta PRDM10 VGNC VGNC:76250
Rattus norvegicus PRDM10 RGD RGD:1560384
Mus musculus PRDM10 MGD MGI:2682952
Others PRDM10 NCBI