RAD1 - RAD1 checkpoint DNA exonuclease Gene

Also Known as REC1; HRAD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5810

About RAD1

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:34,905,260-34,915,504 (from NCBI)

This gene has 7 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 6.2), adrenal (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and Other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

RAD1 Products (1)

mRNA Protein Name
NM_002853.4 NP_002844.1 cell cycle checkpoint protein RAD1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10359610 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
21659603 GOA
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
21659603 GOA
involved in meiotic recombination checkpoint signaling IGI
IGI: Inferred from genetic interaction
9716408 GOA
Cellular Component GO Annotation Evidence References Source
part of checkpoint clamp complex IDA
IDA: Inferred from direct assay
31776186 GOA
located in chromosome IDA
IDA: Inferred from direct assay
9716408 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
9716408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD1 Protein Structure

Rad1

Rad1: Repair protein Rad1/Rec1/Rad17 (17 - 257)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

cell cycle checkpoint protein RAD1

  • DNA repair exonuclease REC1

RAD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAD1 O60671 HUS1 Homo sapiens O60921
Y2H
10359610
Intra
RAD1 O60671 RAD9A Homo sapiens Q99638
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS04481 ERCC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11596 RAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12022 RNASE6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12275 RRAD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20332 Rad1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26840 Rad1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAD1 VGNC VGNC:110439
Rattus norvegicus RAD1 RGD RGD:1306496
Felis catus RAD1 VGNC VGNC:102301
Canis familiaris RAD1 VGNC VGNC:45310
Mus musculus RAD1 MGD MGI:1316678
Bos taurus RAD1 VGNC VGNC:33677
Others RAD1 NCBI