ATG101 - autophagy related 101 Gene

Also Known as C12orf44

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 60673

About ATG101

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,065,300-52,077,495 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 16.2), thyroid (RPKM 14.2) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in autophagosome assembly. Located in phagophore assembly site. [provided by Alliance of Genome Resources, Apr 2022]

ATG101 Products (2)

mRNA	Protein	Name
NM_001098673.2	NP_001092143.1	autophagy-related protein 101
NM_021934.5	NP_068753.2	autophagy-related protein 101

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19597335	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19597335	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19225151	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19597335	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21795849	GOA
involved in regulation of protein lipidation	IDA IDA: Inferred from direct assay	19225151	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	19597335	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	19597335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG101 Protein Structure

ATG101

0
100
200
218 a.a.

Protein Preferred Names	Protein Names
autophagy-related protein 101	Atg13-interacting protein

ATG101 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATG101	Q9BSB4	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	33961781
Intra	ATG101	Q9BSB4	RB1CC1	Homo sapiens	Q8TDY2	Crosslink	23392225
Intra	ATG101	Q9BSB4	RB1CC1	Homo sapiens	Q8TDY2	Anti Bait CoIP	19597335
Intra	ATG101	Q9BSB4	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	35271311
Intra	ATG101	Q9BSB4	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	ATG101	Q9BSB4	ATG13	Homo sapiens	O75143	Anti Tag CoIP	19597335
Intra	ATG101	Q9BSB4	ATG13	Homo sapiens	O75143	Anti Tag CoIP	35271311
Intra	ATG101	Q9BSB4	ATG13	Homo sapiens	O75143	Anti Tag CoIP	20562859
Intra	ATG101	Q9BSB4	ATG13	Homo sapiens	O75143	Anti Tag CoIP	33961781
Intra	ATG101	Q9BSB4	ATG13	Homo sapiens	O75143	Crosslink	23392225
Intra	ATG101	Q9BSB4	ATG13	Homo sapiens	O75143	Anti Bait CoIP	19597335
Intra	ATG101	Q9BSB4	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ATG101	Q9BSB4	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Cross	ATG101	Q9BSB4	Atg13	Mus musculus	Q91YI1	Anti Tag CoIP	26030876

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	상품명	효과	Purity	Phase
HY-P990778	Xirestomig	Inhibitor	98.44%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-176451	CDK9 degrader-1	Degrader	/	Unkown
HY-181815	SBP-5147		/	Unkown
HY-RS01139	ATG101 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ATG101	VGNC	VGNC:26249
Canis familiaris	ATG101	VGNC	VGNC:38215
Macaca mulatta	ATG101	VGNC	VGNC:70132
Mus musculus	ATG101	MGD	MGI:1915368
Felis catus	ATG101	VGNC	VGNC:59995
Rattus norvegicus	ATG101	RGD	RGD:1359310
Others	ATG101	NCBI