Zfand2b - zinc finger, AN1 type domain 2B Gene

Also Known as 1110060O18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68818

Summary

Enables K48-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; and regulation of insulin-like growth factor receptor signaling pathway. Located in endoplasmic reticulum and membrane. Part of Proteasome complex. Orthologous to human ZFAND2B (zinc finger AN1-type containing 2B). [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in colon adult (RPKM 27.4), large intestine adult (RPKM 24.8) and 28 other tissues.

Zfand2b Products (3)

mRNA Protein Name
NM_001159905.1 NP_001153377.1 AN1-type zinc finger protein 2B
NM_001159906.1 NP_001153378.1 AN1-type zinc finger protein 2B
NM_026846.3 NP_081122.2 AN1-type zinc finger protein 2B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
26876100 MGI
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
24160817 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18467495 MGI
enables ubiquitin binding IDA
IDA: Inferred from direct assay
18467495 MGI
Biological Process GO Annotation Evidence References Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26692333 MGI
involved in protein targeting to ER IMP
IMP: Inferred from mutant phenotype
26692333 MGI
involved in regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26692333 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18467495 MGI
located in membrane IDA
IDA: Inferred from direct assay
18467495 MGI
part of proteasome complex IDA
IDA: Inferred from direct assay
18467495 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Zfand2b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Zfand2b Q91X58 Psma1 Mus musculus Q9R1P4
Anti Bait CoIP
18467495
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Zfand2b NCBI NCBI:130617