ADAM9 - ADAM metallopeptidase domain 9 Gene

Also Known as MCMP; MDC9; CORD9; Mltng

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8754

About ADAM9

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,996,973-39,105,261 (from NCBI)

This gene has 28 transcripts (splice variants), 1 gene allele, 211 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

ADAM9 Products (1)

mRNA	Protein	Name
NM_003816.3	NP_003807.1	disintegrin and metalloproteinase domain-containing protein 9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	10531379	GOA
enables collagen binding	IMP IMP: Inferred from mutant phenotype	15361064	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	15361064	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	17704059	GOA
enables laminin binding	IMP IMP: Inferred from mutant phenotype	15361064	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	9920899	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	22480688	GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IDA IDA: Inferred from direct assay	12054541	GOA
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	12535668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10527948	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid precursor protein catabolic process	IDA IDA: Inferred from direct assay	12054541	GOA
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	17704059	GOA
involved in cell-cell adhesion mediated by integrin	IEP IEP: Inferred from expression pattern	17704059	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	15361064	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	22480688	GOA
involved in keratinocyte differentiation	IEP IEP: Inferred from expression pattern	17704059	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	9920899	GOA
acts upstream of or within membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	23437250	GOA
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	22480688	GOA
acts upstream of or within membrane protein intracellular domain proteolysis	IMP IMP: Inferred from mutant phenotype	23437250	GOA
involved in monocyte activation	IMP IMP: Inferred from mutant phenotype	11831872	GOA
acts upstream of positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	17704059	GOA
involved in positive regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	23437250	GOA
involved in positive regulation of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	17704059	GOA
involved in positive regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	11831872	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	17704059	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	12054541	GOA
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	17018608	GOA
involved in response to manganese ion	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	11831872	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11955914	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12054541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM9 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
819 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 9	ADAM metallopeptidase domain 9 (meltrin gamma)

ADAM9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAM9	Q13443	SNX18	Homo sapiens	Q96RF0	Peptide Array	25825872
Intra	ADAM9	Q13443	SNX18	Homo sapiens	Q96RF0	Phage Display	25825872

Cross: Cross-species interaction Intra: Intraspecies interaction

ADAM9 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81683	ADAM9 Antibody (YA1428)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Cone-Rod Dystrophy 9	CORD9 Dystrophy, Cone-Rod, Type 9 Retinitis Pigmentosa 9
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Retinal Degeneration	Degeneration Of Retina
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	상품명	효과	Purity	Phase
HY-P990027	Izeltabart	Inhibitor	98.62%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-139441	DM21	Inhibitor	99.34%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.54%	Unkown
HY-124813	PDZ1i	Inhibitor	99.29%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2	Substrate	99.33%	Unkown
HY-RS00289	ADAM9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17598	Adam9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24058	Adam9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADAM9	VGNC	VGNC:59585
Mus musculus	ADAM9	MGD	MGI:105376
Bos taurus	ADAM9	VGNC	VGNC:25613
Macaca mulatta	ADAM9	VGNC	VGNC:82097
Rattus norvegicus	ADAM9	RGD	RGD:621473
Canis familiaris	ADAM9	VGNC	VGNC:37588
Others	ADAM9	NCBI