LRRFIP1 - LRR binding FLII interacting protein 1 Gene

Also Known as GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9208

About LRRFIP1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,627,587-237,781,643 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 14.3), bone marrow (RPKM 12.6) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRFIP1 Products (5)

mRNA Protein Name
NM_001137550.2 NP_001131022.1 leucine-rich repeat flightless-interacting protein 1 isoform 1
NM_001137551.2 NP_001131023.1 leucine-rich repeat flightless-interacting protein 1 isoform 2
NM_001137552.2 NP_001131024.1 leucine-rich repeat flightless-interacting protein 1 isoform 3
NM_001137553.2 NP_001131025.1 leucine-rich repeat flightless-interacting protein 1 isoform 5
NM_004735.4 NP_004726.2 leucine-rich repeat flightless-interacting protein 1 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
23099021 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14522076 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14522076 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9671805 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
23099021 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14522076 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRFIP1 Protein Structure

LRRFIP

LRRFIP: LRRFIP family (23 - 316)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat flightless-interacting protein 1

  • GC-binding factor 2

LRRFIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRFIP1 Q32MZ4 FLII Homo sapiens Q13045
Anti Tag CoIP
33961781
Intra
LRRFIP1 Q32MZ4 FLII Homo sapiens Q13045
Pull Down
9671805
Cross: Cross-species interaction Intra: Intraspecies interaction

LRRFIP1 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P85441 LRRFIP1 Antibody (YA5133) WB Human
HY-P85550 LRRFIP1 Antibody (YA5242) WB Human, Mouse

Related Diseases

Diseases Alias
Marasmus

  • Nutritional Marasmus

  • Nutritional Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS07830 LRRFIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LRRFIP1 VGNC VGNC:59085
Macaca mulatta LRRFIP1 VGNC VGNC:99376
Mus musculus LRRFIP1 MGD MGI:1342770
Rattus norvegicus LRRFIP1 RGD RGD:1359548
Bos taurus LRRFIP1 VGNC VGNC:55253
Felis catus LRRFIP1 VGNC VGNC:107576
Others LRRFIP1 NCBI